Sustained IL-1β expression impairs adult hippocampal neurogenesis independent of IL-1 signaling in nestin+ neural precursor cells

Highlight • Impaired adult hippocampal neurogenesis does not depend on intrinsic MyD88 dependent signaling in the setting of neuroinflammation driven by sustained IL-1β expression.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2013-08, Vol.32, p.9-18
Hauptverfasser:	Wu, Michael D, Montgomery, Sara L, Rivera-Escalera, Fatima, Olschowka, John A, O’Banion, M. Kerry
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology Animals Antineoplastic Agents, Hormonal - toxicity Astrocytes Astrocytes - drug effects Astrocytes - physiology Dependovirus - genetics Female Flow Cytometry Hippocampus - cytology Hippocampus - growth & development Immunohistochemistry Interleukin-1 Interleukin-1beta - biosynthesis Male Mice Mice, Knockout MyD88 Myeloid Differentiation Factor 88 - biosynthesis Myeloid Differentiation Factor 88 - genetics Nestin Nestin - genetics Nestin - physiology Neural Stem Cells - metabolism Neural Stem Cells - physiology Neurogenesis Neurogenesis - physiology Neuroinflammation Psychiatry Real-Time Polymerase Chain Reaction Receptors, Interleukin-1 - biosynthesis RNA - biosynthesis RNA - isolation & purification Signal Transduction - physiology Tamoxifen - toxicity
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Beschreibung
Zusammenfassung:	Highlight • Impaired adult hippocampal neurogenesis does not depend on intrinsic MyD88 dependent signaling in the setting of neuroinflammation driven by sustained IL-1β expression.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2013.03.003