Supramolecular filaments containing a fixed 41% paclitaxel loading

We report here the self-assembly of a rationally designed paclitaxel drug amphiphile into well-defined supramolecular filaments that possess a fixed 41% paclitaxel loading. These filaments can exert effective cytotoxicity against a number of cell lines comparable to that of free paclitaxel.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2013-05, Vol.49 (43), p.4968-4970
Hauptverfasser:	Lin, Ran, Cheetham, Andrew G, Zhang, Pengcheng, Lin, Yi-an, Cui, Honggang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - chemistry cell lines Cell Survival - drug effects chemical communication chemical reactions cytotoxicity Drug Carriers - administration & dosage Drug Carriers - chemistry drugs Glutathione - chemistry Humans MCF-7 Cells Microscopy, Electron, Transmission Nanofibers - administration & dosage Nanofibers - chemistry Nanofibers - ultrastructure Oligopeptides - chemistry paclitaxel Paclitaxel - administration & dosage Paclitaxel - chemistry surfactants tau Proteins - chemistry
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Beschreibung
Zusammenfassung:	We report here the self-assembly of a rationally designed paclitaxel drug amphiphile into well-defined supramolecular filaments that possess a fixed 41% paclitaxel loading. These filaments can exert effective cytotoxicity against a number of cell lines comparable to that of free paclitaxel.
ISSN:	1359-7345 1364-548X 1364-548X
DOI:	10.1039/c3cc41896k