Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors

A series of self-immolative boronic ester protected methyl salicylates and metal-binding groups with various linking strategies have been investigated for their use in the design of matrix metalloproteinase proinhibitors.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2011-07, Vol.47 (28), p.7968-7970
Hauptverfasser:	Jourden, Jody L Major, Daniel, Kevin B, Cohen, Seth M
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Design Hydrogen Peroxide - chemistry Matrix Metalloproteinase Inhibitors Matrix Metalloproteinases - chemistry Matrix Metalloproteinases - metabolism Metals - metabolism Protease Inhibitors - chemistry Protease Inhibitors - metabolism Protease Inhibitors - pharmacology
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Beschreibung
Zusammenfassung:	A series of self-immolative boronic ester protected methyl salicylates and metal-binding groups with various linking strategies have been investigated for their use in the design of matrix metalloproteinase proinhibitors.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c1cc12526e