Nucleic Acid-Gold Nanoparticle Conjugates as Mimics of microRNA

Nucleic Acid-Gold Nanoparticle Conjugates as Mimics of microRNA

Novel conjugates of gold nanoparticles functionalized with synthetic microRNAs can enter cells without the aid of cationic co‐carriers and mimic the function of endogenous microRNAs. These conjugates can regulate multiple proteins through interactions with the 3′ untranslated region of the target me...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2011-11, Vol.7 (22), p.3158-3162
Hauptverfasser: Hao, Liangliang, Patel, Pinal C., Alhasan, Ali H., Giljohann, David A., Mirkin, Chad A.
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
cancer therapy
Cell Line, Tumor
Cell Movement
Cell Proliferation
gene regulation
Gold - chemistry
gold nanoparticles
Humans
Male
Metal Nanoparticles - chemistry
microRNA
MicroRNAs - genetics
MicroRNAs - metabolism
Molecular Sequence Data
Nucleic Acids - metabolism
Protein Kinase C-epsilon - metabolism
siRNA
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Zusammenfassung:Novel conjugates of gold nanoparticles functionalized with synthetic microRNAs can enter cells without the aid of cationic co‐carriers and mimic the function of endogenous microRNAs. These conjugates can regulate multiple proteins through interactions with the 3′ untranslated region of the target messenger RNA and control cell behavior. The conjugates are promising new tools for studying microRNA function and are candidates for microRNA replacement therapies.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201101018