Obstructing Toxin Pathways by Targeted Pore Blockage

Nestorovich and Berzukov provide a detailed analysis of ion channel-forming toxins. These channel-forming toxins are classified as endotoxins and exotoxins, as well as binary toxins. Potential uses for bacterial toxins are biosensors and cancer therapies.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical reviews 2012-12, Vol.112 (12), p.6388-6430
Hauptverfasser:	Nestorovich, Ekaterina M, Bezrukov, Sergey M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Animals Bacteria Bacterial proteins Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - chemistry Bacterial Proteins - metabolism Bacterial Toxins - antagonists & inhibitors Bacterial Toxins - chemistry Bacterial Toxins - metabolism Biosensors Blockage Blocking Cancer Cancer therapies Endotoxins Humans Ions Models, Molecular Pathways Porins - antagonists & inhibitors Porins - chemistry Porins - metabolism Porosity Toxins
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Beschreibung
Zusammenfassung:	Nestorovich and Berzukov provide a detailed analysis of ion channel-forming toxins. These channel-forming toxins are classified as endotoxins and exotoxins, as well as binary toxins. Potential uses for bacterial toxins are biosensors and cancer therapies.
ISSN:	0009-2665 1520-6890
DOI:	10.1021/cr300141q