A vitamin-responsive mesoporous nanocarrier with DNA aptamer-mediated cell targeting

A smart drug delivery system with cancer cell targeting and bioresponsive controlled drug release has been constructed by taking advantage of the protein-capped mesoporous nanovalve and a DNA aptamer.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2013-07, Vol.49 (52), p.5823-5825
Hauptverfasser:	Li, Le-Le, Xie, Mengying, Wang, Jie, Li, Xinyang, Wang, Cheng, Yuan, Quan, Pang, Dai-Wen, Lu, Yi, Tan, Weihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aptamers, Nucleotide - chemistry Avidin - chemistry Avidin - metabolism Biotin - chemistry Biotin - metabolism Cell Line, Tumor Cell Survival - drug effects chemical communication chemical compounds chemical reactions DNA Doxorubicin - chemistry Doxorubicin - toxicity Drug Carriers - chemistry Humans nanocarriers Nanoparticles - chemistry neoplasm cells neoplasms oligonucleotides Porosity porous media Silicon Dioxide - chemistry Vitamins - chemistry Vitamins - metabolism
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Beschreibung
Zusammenfassung:	A smart drug delivery system with cancer cell targeting and bioresponsive controlled drug release has been constructed by taking advantage of the protein-capped mesoporous nanovalve and a DNA aptamer.
ISSN:	1359-7345 1364-548X 1364-548X
DOI:	10.1039/c3cc41072b