Lack of influence of prion protein gene expression on kainate-induced seizures in mice: Studies using congenic, coisogenic and transgenic strains

Highlights ► PrP knockout partially reduces kainate seizure sensitivity in C57BL/10SnJ mice. ► Reintroduction of PrP-transgene in knockout fails to restore original phenotype. ► PrP knockout in coisogenic 129 mice slightly increases kainate seizure sensitivity.

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Veröffentlicht in:	Neuroscience 2013-05, Vol.238, p.11-18
Hauptverfasser:	Striebel, J.F, Race, B, Pathmajeyan, M, Rangel, A, Chesebro, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences flanking genes Fundamental and applied biological sciences. Psychology Gene Expression Genetic Predisposition to Disease Kainic Acid knockout mice Mice Mice, Transgenic Neurology Neurons - metabolism prion Prions - genetics Prions - metabolism Prnp seizures Seizures - chemically induced Seizures - genetics Seizures - metabolism Species Specificity Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights ► PrP knockout partially reduces kainate seizure sensitivity in C57BL/10SnJ mice. ► Reintroduction of PrP-transgene in knockout fails to restore original phenotype. ► PrP knockout in coisogenic 129 mice slightly increases kainate seizure sensitivity.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.02.004