A Unified Synthetic Strategy to the Cryptocarya Family of Natural Products Exploiting Anion Relay Chemistry (ARC)

A Unified Synthetic Strategy to the Cryptocarya Family of Natural Products Exploiting Anion Relay Chemistry (ARC)

A unified synthetic strategy to the Cryptocarya family of natural products has been achieved employing four-component fragment unions in a “single flask” exploiting Anion Relay Chemistry (ARC). Functionalization of the ARC adducts permits rapid construction of five polyhydroxylated di- and tetrahydr...

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Veröffentlicht in:Organic letters 2013-05, Vol.15 (9), p.2282-2285
Hauptverfasser: Melillo, Bruno, Smith, Amos B
Format: Artikel
Sprache:eng
Schlagworte:
Anions - chemistry
Biological Products - chemistry
Combinatorial Chemistry Techniques
Cryptocarya - chemistry
Molecular Structure
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Zusammenfassung:A unified synthetic strategy to the Cryptocarya family of natural products has been achieved employing four-component fragment unions in a “single flask” exploiting Anion Relay Chemistry (ARC). Functionalization of the ARC adducts permits rapid construction of five polyhydroxylated di- and tetrahydropyrone natural products of the Cryptocarya class (1–5), in a total of 7–9 steps from commercially available materials.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol400857k