Stress, kappa manipulations, and aversive effects of ethanol in adolescent and adult male rats

Highlights ► Stress had no effect on ethanol-induced CTA in adolescents or adults. ► Among stressed adults only, kappa antagonism attenuated ethanol-induced CTA. ► Stressed adolescents and adults were less sensitive to kappa agonist-induced CTA.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2013-09, Vol.249, p.214-222
Hauptverfasser:	Anderson, R.I, Agoglia, A.E, Morales, M, Varlinskaya, E.I, Spear, L.P
Format:	Artikel
Sprache:	eng
Schlagworte:	adolescence Age Factors Animals Avoidance Learning - drug effects Avoidance Learning - physiology Biological and medical sciences conditioned taste aversion Dose-Response Relationship, Drug ethanol Ethanol - administration & dosage Fundamental and applied biological sciences. Psychology kappa opioid receptor Male Neurology Olfactory system and olfaction. Gustatory system and gustation Pyrrolidines - administration & dosage Random Allocation rat Rats Rats, Sprague-Dawley Receptors, Opioid, kappa - agonists Receptors, Opioid, kappa - metabolism stress Taste - drug effects Taste - physiology Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights ► Stress had no effect on ethanol-induced CTA in adolescents or adults. ► Among stressed adults only, kappa antagonism attenuated ethanol-induced CTA. ► Stressed adolescents and adults were less sensitive to kappa agonist-induced CTA.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.12.028