Identification of serum microRNA profiles in colon cancer

Background: microRNAs (miRNAs) exist in blood in an apparently stable form. We have explored whether serum miRNAs can be used as non-invasive early biomarkers of colon cancer. Methods: Serum samples from 30 patients with colon cancer stage IV and 10 healthy controls were examined for the expression...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of cancer 2013-04, Vol.108 (8), p.1712-1719
Hauptverfasser:	Hofsli, E, Sjursen, W, Prestvik, W S, Johansen, J, Rye, M, Tranø, G, Wasmuth, H H, Hatlevoll, I, Thommesen, L
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/384/331 692/699/67/1504/1885/1393 692/699/67/1857 Biological and medical sciences Biomarkers Biomedical and Life Sciences Biomedicine Blood & organ donations Cancer Research Case-Control Studies Colonic Neoplasms - blood Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colorectal cancer Drug Resistance Epidemiology Female Gastroenterology. Liver. Pancreas. Abdomen Hospitals Humans Linear Models Male Medical sciences Metastasis MicroRNAs MicroRNAs - blood Middle Aged Molecular Diagnostics Molecular Medicine Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Staging Oncology Patients Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background: microRNAs (miRNAs) exist in blood in an apparently stable form. We have explored whether serum miRNAs can be used as non-invasive early biomarkers of colon cancer. Methods: Serum samples from 30 patients with colon cancer stage IV and 10 healthy controls were examined for the expression of 375 cancer-relevant miRNAs. Based on the miRNA profile in this study, 34 selected miRNAs were measured in serum from 40 patients with stage I–II colon cancer and from 10 additional controls. Results: Twenty miRNAs were differentially expressed in serum from stage IV patients compared with controls ( P
ISSN:	0007-0920 1532-1827
DOI:	10.1038/bjc.2013.121