Lesions of the ventral premammillary nucleus disrupt the dynamic changes in Kiss1 and GnRH expression characteristic of the proestrus–estrus transition

Highlights • Changes in sex steroid levels modulate the expression of ERα in the PMV. • Bilateral lesions of the PMV decrease receptive (lordosis) behavior. • PMV-lesioned rats exhibit abnormal Kiss1 and GnRH mRNA expression in the estrus night.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2013-06, Vol.241, p.67-79
Hauptverfasser:	Donato, J, Lee, C, Ratra, D.V, Franci, C.R, Canteras, N.S, Elias, C.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Estrus - physiology Female Fundamental and applied biological sciences. Psychology Gonadal Steroid Hormones - metabolism Gonadotropin-Releasing Hormone - biosynthesis HPG axis hypothalamus Hypothalamus - injuries Hypothalamus - metabolism Immunohistochemistry In Situ Hybridization Kisspeptins - biosynthesis lordosis Male neuroendocrinology Neurology Proestrus - physiology Radioimmunoassay Rats Rats, Sprague-Dawley Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Sexual Behavior, Animal - physiology Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights • Changes in sex steroid levels modulate the expression of ERα in the PMV. • Bilateral lesions of the PMV decrease receptive (lordosis) behavior. • PMV-lesioned rats exhibit abnormal Kiss1 and GnRH mRNA expression in the estrus night.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.03.013