MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma
Highlights ► Spontaneous development of HNSCC in Tgfbr1/Pten 2cKO mice results in miR-135b overexpression. ► The oncogenic potential of increased miR-135b expression mainly correlates to Tgfbr1 deletion. ► miR-135b promotes angiogenesis potential of HUVEC in HNSCC mice. ► miR-135b decreases FIH expr...
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| Veröffentlicht in: | Cancer letters 2013-05, Vol.331 (2), p.230-238 |
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| container_title | Cancer letters |
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| creator | Zhang, Lu Sun, Zhi-Jun Bian, Yansong Kulkarni, Ashok B |
| description | Highlights ► Spontaneous development of HNSCC in Tgfbr1/Pten 2cKO mice results in miR-135b overexpression. ► The oncogenic potential of increased miR-135b expression mainly correlates to Tgfbr1 deletion. ► miR-135b promotes angiogenesis potential of HUVEC in HNSCC mice. ► miR-135b decreases FIH expression and increases expression of HIF-1α and VEGFA in HNSCC. |
| doi_str_mv | 10.1016/j.canlet.2013.01.003 |
| format | Article |
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genetics</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell growth</subject><subject>Cell Proliferation</subject><subject>Cells, Cultured</subject><subject>Colorectal cancer</subject><subject>correlation</subject><subject>Disease Models, Animal</subject><subject>Gene Deletion</subject><subject>Gene expression</subject><subject>gene silencing</subject><subject>head</subject><subject>Head and neck cancer</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Head and Neck Neoplasms - metabolism</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Hypoxia-Inducible Factor 1 - metabolism</subject><subject>Metastasis</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>MicroRNA</subject><subject>MicroRNAs - physiology</subject><subject>Mouse model</subject><subject>Mutation</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>PTEN Phosphohydrolase - genetics</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Receptor, Transforming Growth Factor-beta Type I</subject><subject>Receptors, Transforming Growth Factor beta - genetics</subject><subject>Rodents</subject><subject>squamous cell carcinoma</subject><subject>Studies</subject><subject>Tumorigenesis</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUstu1TAUjBCIlsIfILDUDZtcjh95bZCqipdUQKJ0bTn2yb2-TexbOynkf_hQHN3SQjeVLHvhmdGZOZNlLymsKNDy7XalletxXDGgfAV0BcAfZYe0rlheNTU8zg6Bg8h5zYuD7FmMWwAoRFU8zQ4Y5wJoDYfZ7y9WB__960lOedESpcdIVDpknAYfyC74wY8YSDuTUYU1jtatybhBspl3_pdVuXVm0rbtkXSJvFDUuPmpZmIdWaNLBK36fiYGO-vQkMFPEdNtsCe-IxtUhihniEN9SeLVpBYA0dj3RKugrfODep496VQf8cXNe5RdfHj_4_RTfvbt4-fTk7NcV8DGvOIpAl2XplRVK2ojDC90U3LeMGNErTootG4BNK94pTV2JmVAVS04r0Tddfwoe7fX3U3tgEajG4Pq5S7YQYVZemXl_z_ObuTaX0telmkJZRJ4cyMQ_NWEcZSDjYsX5TDZkrSqC8YaJsTDUNGwkjLaVAl6fA-69VNwKQlJS1EAZTU0CSX2qLTPGAN2t3NTkEtj5FbuGyOXxkigMsWVaK_-9XxL-luRBHi9B3TKS7UONsqL86RQwELnrLmLDdNuri0GGbVFp9HYgHqUxtuHZrgvoHvrluJc4ozxzq2MTII8X3q91JqmhQNjwP8ABX3zgg</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Zhang, Lu</creator><creator>Sun, Zhi-Jun</creator><creator>Bian, Yansong</creator><creator>Kulkarni, Ashok B</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20130501</creationdate><title>MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma</title><author>Zhang, Lu ; Sun, Zhi-Jun ; Bian, Yansong ; Kulkarni, Ashok B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c702t-73003c86d6a7b48d4d35c963392dd48af05ccb00c3737ccefd0181a8433748ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Angiogenesis</topic><topic>animal models</topic><topic>Animals</topic><topic>Blotting, Western</topic><topic>Breast cancer</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell growth</topic><topic>Cell Proliferation</topic><topic>Cells, Cultured</topic><topic>Colorectal cancer</topic><topic>correlation</topic><topic>Disease Models, Animal</topic><topic>Gene Deletion</topic><topic>Gene expression</topic><topic>gene silencing</topic><topic>head</topic><topic>Head and neck cancer</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Head and Neck Neoplasms - metabolism</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Hypoxia-Inducible Factor 1 - metabolism</topic><topic>Metastasis</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>MicroRNA</topic><topic>MicroRNAs - physiology</topic><topic>Mouse model</topic><topic>Mutation</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>PTEN Phosphohydrolase - genetics</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Receptor, Transforming Growth Factor-beta Type I</topic><topic>Receptors, Transforming Growth Factor beta - genetics</topic><topic>Rodents</topic><topic>squamous cell carcinoma</topic><topic>Studies</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Lu</creatorcontrib><creatorcontrib>Sun, Zhi-Jun</creatorcontrib><creatorcontrib>Bian, Yansong</creatorcontrib><creatorcontrib>Kulkarni, Ashok B</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Lu</au><au>Sun, Zhi-Jun</au><au>Bian, Yansong</au><au>Kulkarni, Ashok B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>331</volume><issue>2</issue><spage>230</spage><epage>238</epage><pages>230-238</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Highlights ► Spontaneous development of HNSCC in Tgfbr1/Pten 2cKO mice results in miR-135b overexpression. ► The oncogenic potential of increased miR-135b expression mainly correlates to Tgfbr1 deletion. ► miR-135b promotes angiogenesis potential of HUVEC in HNSCC mice. ► miR-135b decreases FIH expression and increases expression of HIF-1α and VEGFA in HNSCC.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>23340180</pmid><doi>10.1016/j.canlet.2013.01.003</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2013-05, Vol.331 (2), p.230-238 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Angiogenesis animal models Animals Blotting, Western Breast cancer Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell growth Cell Proliferation Cells, Cultured Colorectal cancer correlation Disease Models, Animal Gene Deletion Gene expression gene silencing head Head and neck cancer Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Hematology, Oncology and Palliative Medicine Humans Hypoxia Hypoxia-Inducible Factor 1 - metabolism Metastasis Mice Mice, Knockout MicroRNA MicroRNAs - physiology Mouse model Mutation Protein-Serine-Threonine Kinases - genetics PTEN Phosphohydrolase - genetics Real-Time Polymerase Chain Reaction Receptor, Transforming Growth Factor-beta Type I Receptors, Transforming Growth Factor beta - genetics Rodents squamous cell carcinoma Studies Tumorigenesis |
| title | MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma |
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