MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma

Highlights ► Spontaneous development of HNSCC in Tgfbr1/Pten 2cKO mice results in miR-135b overexpression. ► The oncogenic potential of increased miR-135b expression mainly correlates to Tgfbr1 deletion. ► miR-135b promotes angiogenesis potential of HUVEC in HNSCC mice. ► miR-135b decreases FIH expr...

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Veröffentlicht in:	Cancer letters 2013-05, Vol.331 (2), p.230-238
Hauptverfasser:	Zhang, Lu, Sun, Zhi-Jun, Bian, Yansong, Kulkarni, Ashok B
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis animal models Animals Blotting, Western Breast cancer Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell growth Cell Proliferation Cells, Cultured Colorectal cancer correlation Disease Models, Animal Gene Deletion Gene expression gene silencing head Head and neck cancer Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Hematology, Oncology and Palliative Medicine Humans Hypoxia Hypoxia-Inducible Factor 1 - metabolism Metastasis Mice Mice, Knockout MicroRNA MicroRNAs - physiology Mouse model Mutation Protein-Serine-Threonine Kinases - genetics PTEN Phosphohydrolase - genetics Real-Time Polymerase Chain Reaction Receptor, Transforming Growth Factor-beta Type I Receptors, Transforming Growth Factor beta - genetics Rodents squamous cell carcinoma Studies Tumorigenesis
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Zusammenfassung:	Highlights ► Spontaneous development of HNSCC in Tgfbr1/Pten 2cKO mice results in miR-135b overexpression. ► The oncogenic potential of increased miR-135b expression mainly correlates to Tgfbr1 deletion. ► miR-135b promotes angiogenesis potential of HUVEC in HNSCC mice. ► miR-135b decreases FIH expression and increases expression of HIF-1α and VEGFA in HNSCC.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.01.003