Microfluidic Generation of Acoustically Active Nanodroplets

A microfluidic approach for the generation of perfluorocarbon nanodroplets as the primary emulsion with diameters as small as 300–400 nm is described. The system uses a pressure‐controlled delivery of all reagents and increased viscosity in the continuous phase to drive the device into an advanced tip‐streaming regime, which results in generation of droplets in the sub‐micrometer range. Such nanodroplets may be appropriate for emerging biomedical applications.