Effects of ceftriaxone on the acquisition and maintenance of ethanol drinking in peri-adolescent and adult female alcohol-preferring (P) rats

Highlights • CEF treatment reduced the maintenance of ethanol intake. • The beneficial effect of CEF was pronounced in rats pretreated with CEF. • Reductions in ethanol intake were paralleled by an upregulation of GLT1 levels.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2013-06, Vol.241, p.229-238
Hauptverfasser:	Sari, Y, Franklin, K.M, Alazizi, A, Rao, P.S.S, Bell, R.L
Format:	Artikel
Sprache:	eng
Schlagworte:	acquisition Alcohol Drinking - metabolism Alcohol Drinking - prevention & control Alcoholism - metabolism Animals Anti-Bacterial Agents - pharmacology Biological and medical sciences Blotting, Western Brain - drug effects Brain - metabolism ceftriaxone Ceftriaxone - pharmacology EAAT2 Female Fundamental and applied biological sciences. Psychology Glucose Transporter Type 1 - metabolism maintenance Neurology Rats Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights • CEF treatment reduced the maintenance of ethanol intake. • The beneficial effect of CEF was pronounced in rats pretreated with CEF. • Reductions in ethanol intake were paralleled by an upregulation of GLT1 levels.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.03.016