In vivo imaging and evaluation of different biomatrices for improvement of stem cell survival

Therapeutic effects from injection of stem cells are often hampered by acute donor cell death as well as migration away from damaged areas. This is likely due to the fact that injected cells do not have the physical and biochemical cues for ordered engrafment. Here we evaluate 3 common biomatrices (...

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Veröffentlicht in:	Journal of tissue engineering and regenerative medicine 2007-11, Vol.1 (6), p.465-468
Hauptverfasser:	Cao, Feng, Sadrzadeh Rafie, Amir H., Abilez, Oscar J., Wang, Haichang, Blundo, Jennifer T., Pruitt, Beth, Zarins, Christopher, Wu, Joseph C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatible Materials - metabolism Biocompatible Materials - pharmacology biomatrices Bone Marrow Cells - cytology Cell Separation Cell Survival - drug effects Collagen I Luminescent Measurements Matrigel Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mice Mice, Transgenic Microscopy, Fluorescence molecular imaging Puramatrix stem cell transplantation tissue engineering Whole Body Imaging - methods
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Zusammenfassung:	Therapeutic effects from injection of stem cells are often hampered by acute donor cell death as well as migration away from damaged areas. This is likely due to the fact that injected cells do not have the physical and biochemical cues for ordered engrafment. Here we evaluate 3 common biomatrices (Matrigel, Collagen I, Purmatrix) that has the potential of providing suitable scaffolds needed to enhance stem cell survival. The longitudinal fate of transplanted stem cells was monitored by reporter imaging techniques. Copyright © 2008 John Wiley & Sons, Ltd.
ISSN:	1932-6254 1932-7005
DOI:	10.1002/term.55