Adduct of Malondialdehyde to Hemoglobin : A New Marker of Oxidative Stress That Is Associated with Significant Morbidity in Preterm Infants

Adduct of Malondialdehyde to Hemoglobin : A New Marker of Oxidative Stress That Is Associated with Significant Morbidity in Preterm Infants

Preterm infants (PT) are particularly exposed to oxidative stress (OS), and a blood-sparing marker, the malondialdehyde adduct to hemoglobin (MDA-Hb), may be useful to accurately assess OS-related neonatal morbidity. In a prospective study, MDA-Hb concentrations were assessed in two groups of PT, on...

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Veröffentlicht in:Oxidative medicine and cellular longevity 2013-01, Vol.2013 (2013), p.1-8
Hauptverfasser: Cipierre, Cécile, Haÿs, Stéphane, Maucort-Boulch, Delphine, Steghens, Jean-Paul, Picaud, Jean-Charles
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers - metabolism
Clinical Study
Female
Glutathione - metabolism
Hemoglobins - metabolism
Humans
Infant, Newborn
Infant, Premature - metabolism
Infant, Very Low Birth Weight
Life Sciences
Male
Malondialdehyde - metabolism
Oxidative Stress
Premature Birth - epidemiology
Premature Birth - pathology
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container_end_page 8
container_issue 2013
container_start_page 1
container_title Oxidative medicine and cellular longevity
container_volume 2013
creator Cipierre, Cécile
Haÿs, Stéphane
Maucort-Boulch, Delphine
Steghens, Jean-Paul
Picaud, Jean-Charles
description Preterm infants (PT) are particularly exposed to oxidative stress (OS), and a blood-sparing marker, the malondialdehyde adduct to hemoglobin (MDA-Hb), may be useful to accurately assess OS-related neonatal morbidity. In a prospective study, MDA-Hb concentrations were assessed in two groups of PT, one with and one without severe neonatal morbidity as estimated by a composite index of severe morbidity (ISM). All PT born in a single tertiary care NICU (
doi_str_mv 10.1155/2013/901253
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In a prospective study, MDA-Hb concentrations were assessed in two groups of PT, one with and one without severe neonatal morbidity as estimated by a composite index of severe morbidity (ISM). All PT born in a single tertiary care NICU (&lt;32 weeks and birth weight &lt;1500 g) were consecutively included. MDA-Hb and blood glutathione (GSH) concentrations were measured by liquid chromatography-mass spectrometry during the first 6 weeks of life. Linear regressions and a multilevel model were fitted to study the relationship between MDA-Hb or GSH and ISM. Of the 83 PT (mean ± SD: 28.3±2 weeks, 1089±288 g), 21% presented severe neonatal morbidity. In the multivariate model, MDA-Hb concentrations were significantly higher in the ISM+ group than in the ISM– group during the first 6 weeks of life (P=0.009). No significant difference in GSH concentrations was observed between groups (P=0.180). MDA-Hb is a marker of interest for estimating oxidative stress in PT and could be useful to evaluate the impact of strategies to improve perinatal outcomes.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2013/901253</identifier><identifier>PMID: 23738045</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Biomarkers - metabolism ; Clinical Study ; Female ; Glutathione - metabolism ; Hemoglobins - metabolism ; Humans ; Infant, Newborn ; Infant, Premature - metabolism ; Infant, Very Low Birth Weight ; Life Sciences ; Male ; Malondialdehyde - metabolism ; Oxidative Stress ; Premature Birth - epidemiology ; Premature Birth - pathology</subject><ispartof>Oxidative medicine and cellular longevity, 2013-01, Vol.2013 (2013), p.1-8</ispartof><rights>Copyright © 2013 Cécile Cipierre et al.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2013 Cécile Cipierre et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-ef137db793c6645bd494c7603e0f9df10f53bc225c675b74c5bcd3bef9a7cc9e3</citedby><cites>FETCH-LOGICAL-c472t-ef137db793c6645bd494c7603e0f9df10f53bc225c675b74c5bcd3bef9a7cc9e3</cites><orcidid>0000-0003-0042-7787</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655681/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655681/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23738045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://univ-lyon1.hal.science/hal-02168108$$DView record in HAL$$Hfree_for_read</backlink></links><search><contributor>Ramana, Kota V.</contributor><creatorcontrib>Cipierre, Cécile</creatorcontrib><creatorcontrib>Haÿs, Stéphane</creatorcontrib><creatorcontrib>Maucort-Boulch, Delphine</creatorcontrib><creatorcontrib>Steghens, Jean-Paul</creatorcontrib><creatorcontrib>Picaud, Jean-Charles</creatorcontrib><title>Adduct of Malondialdehyde to Hemoglobin : A New Marker of Oxidative Stress That Is Associated with Significant Morbidity in Preterm Infants</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Preterm infants (PT) are particularly exposed to oxidative stress (OS), and a blood-sparing marker, the malondialdehyde adduct to hemoglobin (MDA-Hb), may be useful to accurately assess OS-related neonatal morbidity. In a prospective study, MDA-Hb concentrations were assessed in two groups of PT, one with and one without severe neonatal morbidity as estimated by a composite index of severe morbidity (ISM). All PT born in a single tertiary care NICU (&lt;32 weeks and birth weight &lt;1500 g) were consecutively included. MDA-Hb and blood glutathione (GSH) concentrations were measured by liquid chromatography-mass spectrometry during the first 6 weeks of life. Linear regressions and a multilevel model were fitted to study the relationship between MDA-Hb or GSH and ISM. Of the 83 PT (mean ± SD: 28.3±2 weeks, 1089±288 g), 21% presented severe neonatal morbidity. In the multivariate model, MDA-Hb concentrations were significantly higher in the ISM+ group than in the ISM– group during the first 6 weeks of life (P=0.009). No significant difference in GSH concentrations was observed between groups (P=0.180). MDA-Hb is a marker of interest for estimating oxidative stress in PT and could be useful to evaluate the impact of strategies to improve perinatal outcomes.</description><subject>Biomarkers - metabolism</subject><subject>Clinical Study</subject><subject>Female</subject><subject>Glutathione - metabolism</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature - metabolism</subject><subject>Infant, Very Low Birth Weight</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Oxidative Stress</subject><subject>Premature Birth - epidemiology</subject><subject>Premature Birth - pathology</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqFkc9v0zAUxyMEYmNw4gzykR8qs-M4qTkgRdOglTqGtHG2HPu5MSTxsN12_Rv4p3GUUgEXTrb8Pv689_TNsucEvyOEsfMcE3rOMckZfZCdEl7kM8x58fB4x_gkexLCN4xLmhfkcXaS04rOccFOs5-11hsVkTPoSnZu0FZ2Gtq9BhQdWkDv1p1r7IDeoxp9hl2i_HfwI399b7WMdgvoJnoIAd22MqJlQHUITlkZQaOdjS26sevBGqvkENGV843VNu5Rcn7xEMH3aDmYVAtPs0dGdgGeHc6z7OvHy9uLxWx1_Wl5Ua9mqqjyOANDaKWbilNVlgVrdMELVZWYAjZcG4INo43Kc6bKijVVoVijNG3AcFkpxYGeZR8m792m6UErGKKXnbjztpd-L5y04u_KYFuxdltBS8bKOUmC15Og_efbol6J8Q3nJHF4vh3ZV4dm3v3YQIiit0FB18kB3CYIkqR8zjAvEvp2QpV3IXgwRzfBYoxajFGLKepEv_xziyP7O9sEvDlMaQctd_Y_thcTDAkBI48wwyXL5_QXtZe75w</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Cipierre, Cécile</creator><creator>Haÿs, Stéphane</creator><creator>Maucort-Boulch, Delphine</creator><creator>Steghens, Jean-Paul</creator><creator>Picaud, Jean-Charles</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>Hindawi</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0042-7787</orcidid></search><sort><creationdate>20130101</creationdate><title>Adduct of Malondialdehyde to Hemoglobin : A New Marker of Oxidative Stress That Is Associated with Significant Morbidity in Preterm Infants</title><author>Cipierre, Cécile ; 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In a prospective study, MDA-Hb concentrations were assessed in two groups of PT, one with and one without severe neonatal morbidity as estimated by a composite index of severe morbidity (ISM). All PT born in a single tertiary care NICU (&lt;32 weeks and birth weight &lt;1500 g) were consecutively included. MDA-Hb and blood glutathione (GSH) concentrations were measured by liquid chromatography-mass spectrometry during the first 6 weeks of life. Linear regressions and a multilevel model were fitted to study the relationship between MDA-Hb or GSH and ISM. Of the 83 PT (mean ± SD: 28.3±2 weeks, 1089±288 g), 21% presented severe neonatal morbidity. In the multivariate model, MDA-Hb concentrations were significantly higher in the ISM+ group than in the ISM– group during the first 6 weeks of life (P=0.009). No significant difference in GSH concentrations was observed between groups (P=0.180). MDA-Hb is a marker of interest for estimating oxidative stress in PT and could be useful to evaluate the impact of strategies to improve perinatal outcomes.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>23738045</pmid><doi>10.1155/2013/901253</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0042-7787</orcidid><oa>free_for_read</oa></addata></record>
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subjects Biomarkers - metabolism
Clinical Study
Female
Glutathione - metabolism
Hemoglobins - metabolism
Humans
Infant, Newborn
Infant, Premature - metabolism
Infant, Very Low Birth Weight
Life Sciences
Male
Malondialdehyde - metabolism
Oxidative Stress
Premature Birth - epidemiology
Premature Birth - pathology
title Adduct of Malondialdehyde to Hemoglobin : A New Marker of Oxidative Stress That Is Associated with Significant Morbidity in Preterm Infants
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