Adduct of Malondialdehyde to Hemoglobin : A New Marker of Oxidative Stress That Is Associated with Significant Morbidity in Preterm Infants

Adduct of Malondialdehyde to Hemoglobin : A New Marker of Oxidative Stress That Is Associated with Significant Morbidity in Preterm Infants

Preterm infants (PT) are particularly exposed to oxidative stress (OS), and a blood-sparing marker, the malondialdehyde adduct to hemoglobin (MDA-Hb), may be useful to accurately assess OS-related neonatal morbidity. In a prospective study, MDA-Hb concentrations were assessed in two groups of PT, on...

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Veröffentlicht in:Oxidative medicine and cellular longevity 2013-01, Vol.2013 (2013), p.1-8
Hauptverfasser: Cipierre, Cécile, Haÿs, Stéphane, Maucort-Boulch, Delphine, Steghens, Jean-Paul, Picaud, Jean-Charles
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers - metabolism
Clinical Study
Female
Glutathione - metabolism
Hemoglobins - metabolism
Humans
Infant, Newborn
Infant, Premature - metabolism
Infant, Very Low Birth Weight
Life Sciences
Male
Malondialdehyde - metabolism
Oxidative Stress
Premature Birth - epidemiology
Premature Birth - pathology
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Zusammenfassung:Preterm infants (PT) are particularly exposed to oxidative stress (OS), and a blood-sparing marker, the malondialdehyde adduct to hemoglobin (MDA-Hb), may be useful to accurately assess OS-related neonatal morbidity. In a prospective study, MDA-Hb concentrations were assessed in two groups of PT, one with and one without severe neonatal morbidity as estimated by a composite index of severe morbidity (ISM). All PT born in a single tertiary care NICU (
ISSN:1942-0900
1942-0994
DOI:10.1155/2013/901253