The Influence of Nrf2 on Cardiac Responses to Environmental Stressors

Nrf2 protects the lung from adverse responses to oxidants, including 100% oxygen (hyperoxia) and airborne pollutants like particulate matter (PM) exposure, but the role of Nrf2 on heart rate (HR) and heart rate variability (HRV) responses is not known. We hypothesized that genetic disruption of Nrf2...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2013-01, Vol.2013 (2013), p.1-10
Hauptverfasser:	Howden, Reuben, Gougian, Eva, Lawrence, Marcus, Cividanes, Samantha, Gladwell, Wesley, Miller-DeGraff, Laura, Myers, Page H., Rouse, D. Clay, Devlin, Robert B., Cho, Hye-Youn, Kleeberger, Steven R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Environment Heart - drug effects Heart - physiopathology Heart Rate - drug effects Hyperoxia - physiopathology Male Mice Mice, Inbred ICR NF-E2-Related Factor 2 - deficiency NF-E2-Related Factor 2 - metabolism Particle Size Particulate Matter - toxicity Stress, Physiological - drug effects Time Factors
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Zusammenfassung:	Nrf2 protects the lung from adverse responses to oxidants, including 100% oxygen (hyperoxia) and airborne pollutants like particulate matter (PM) exposure, but the role of Nrf2 on heart rate (HR) and heart rate variability (HRV) responses is not known. We hypothesized that genetic disruption of Nrf2 would exacerbate murine HR and HRV responses to severe hyperoxia or moderate PM exposures. Nrf2-/- and Nrf2+/+ mice were instrumented for continuous ECG recording to calculate HR and HRV (low frequency (LF), high frequency (HF), and total power (TP)). Mice were then either exposed to hyperoxia for up to 72 hrs or aspirated with ultrafine PM (UF-PM). Compared to respective controls, UF-PM induced significantly greater effects on HR (P
ISSN:	1942-0900 1942-0994
DOI:	10.1155/2013/901239