Systemic Immune Activation and Microbial Translocation in Dual HIV/Tuberculosis-Infected Subjects

Background. Systemic immune activation is a strong predictor of progression of human immunodeficiency virus type 1 (HIV-1) disease and a prominent feature of infection with Mycobacterium tuberculosis. Objective. To understand the role of systemic immune activation and microbial translocation in HIV/...

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Veröffentlicht in:	The Journal of infectious diseases 2013-06, Vol.207 (12), p.1841-1849
Hauptverfasser:	Toossi, Zahra, Funderburg, Nicholas T., Sirdeshmuk, Sohani, Whalen, Christopher C., Nanteza, Maria W., Johnson, Denise F., Mayanja-Kizza, Harriet, Hirsch, Christina S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiretroviral Therapy, Highly Active Antitubercular Agents - therapeutic use Bacterial Translocation Biological and medical sciences Case-Control Studies CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology Cohort Studies Disease Progression Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Gastrointestinal Tract - microbiology Highly active antiretroviral therapy HIV HIV 1 HIV Infections - complications HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV-1 - immunology HIV/AIDS Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans Infections Infectious diseases Lipopolysaccharide Receptors - blood Lipopolysaccharides - blood Low back pain Major and Brief Reports Male Medical sciences Microbiology Middle Aged Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - physiology Pulmonary tuberculosis T lymphocytes Tuberculosis Tuberculosis, Pulmonary - complications Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - microbiology Uganda Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load
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Zusammenfassung:	Background. Systemic immune activation is a strong predictor of progression of human immunodeficiency virus type 1 (HIV-1) disease and a prominent feature of infection with Mycobacterium tuberculosis. Objective. To understand the role of systemic immune activation and microbial translocation in HIV/tuberculosis dually infected patients over the full spectrum of HIV-1 immunodeficiency, we studied circulating sCD14 and lipopolysaccharide (LPS) and their relationship to HIV-1 activity. Methods. Two cohorts of HIV/tuberculosis subjects defined by CD4 T-cell count at time of diagnosis of tuberculosis were studied: those with low (
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/jit092