Activation of both Group I and Group II metabotropic glutamatergic receptors suppress retinogeniculate transmission

Highlights • Retinogeniculate terminals have metabotropic glutamate receptors (mGluRs). • These include both Groups I and II. • When activated, they reduce retinogeniculate ESPCs. • Corticogeniculate input activates these mGluRs and reduces retinogeniculate ESPCs.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2013-07, Vol.242, p.78-84
Hauptverfasser:	Lam, Y.-W, Sherman, S.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cerebral Cortex - physiology corticothalamic Cyclopropanes - pharmacology Excitatory Amino Acid Agonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Geniculate Bodies - drug effects Geniculate Bodies - physiology Glycine - analogs & derivatives Glycine - pharmacology lateral geniculate nucleus Mice Neural Inhibition - physiology Neural Pathways - drug effects Neural Pathways - physiology Neurology Photic Stimulation Receptors, Metabotropic Glutamate - agonists Receptors, Metabotropic Glutamate - physiology Resorcinols - pharmacology Retina - drug effects Retina - physiology Synaptic Transmission - drug effects Synaptic Transmission - physiology thalamus Thalamus - physiology Vertebrates: nervous system and sense organs Visual Pathways - physiology
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Beschreibung
Zusammenfassung:	Highlights • Retinogeniculate terminals have metabotropic glutamate receptors (mGluRs). • These include both Groups I and II. • When activated, they reduce retinogeniculate ESPCs. • Corticogeniculate input activates these mGluRs and reduces retinogeniculate ESPCs.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.03.043