Tuberculosis after one year of combination antiretroviral therapy in Nigeria: a retrospective cohort study

Our objective was to determine tuberculosis (TB) incidence and evaluate TB risk in adults after one or more years of use of combination antiretroviral therapy (cART) through a retrospective cohort study in Jos, Nigeria. We studied a cohort of HIV-infected adults treated with ART for at least 1 year....

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Veröffentlicht in:	AIDS research and human retroviruses 2013-06, Vol.29 (6), p.931-937
Hauptverfasser:	Akanbi, Maxwell O, Achenbach, Chad J, Feinglass, Joe, Taiwo, Babafemi, Onu, Adamu, Pho, Mai T, Agbaji, Oche, Kanki, Phyllis, Murphy, Robert L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS/HIV Anti-HIV Agents - therapeutic use CD4 Lymphocyte Count Female HIV Infections - complications HIV Infections - drug therapy Human immunodeficiency virus Human immunodeficiency virus 1 Humans Incidence Kaplan-Meier Estimate Male Middle Aged Mycobacterium Nigeria - epidemiology Outcomes Research Proportional Hazards Models Retrospective Studies Retrovirus Risk Factors Time Factors Tuberculosis, Pulmonary - epidemiology Tuberculosis, Pulmonary - etiology Viral Load - drug effects
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Zusammenfassung:	Our objective was to determine tuberculosis (TB) incidence and evaluate TB risk in adults after one or more years of use of combination antiretroviral therapy (cART) through a retrospective cohort study in Jos, Nigeria. We studied a cohort of HIV-infected adults treated with ART for at least 1 year. Based on immunologic and virologic responses to ART, patients were categorized into four groups: CD4 T cell count ≥350 cells/mm(3) and HIV-1 RNA level ≤400 copies/ml (group 1), CD4 T cell count ≥350 cells/mm(3) and HIV-1 RNA level >400 copies/ml (group 2), CD4 T cell count
ISSN:	0889-2229 1931-8405
DOI:	10.1089/AID.2012.0231