Beyond transposons: the epigenetic and somatic functions of the Piwi-piRNA mechanism

Piwi-interacting RNAs (piRNAs) were reported in 2006 as a novel class of small non-coding RNAs associated with Piwi proteins of the Argonaute/Piwi family. Recent studies have revealed not only the biogenesis of piRNAs and their roles in transposon silencing, but also the function of the Piwi-piRNA p...

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Veröffentlicht in:	Current opinion in cell biology 2013-04, Vol.25 (2), p.190-194
Hauptverfasser:	Peng, Jamy C, Lin, Haifan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Argonaute Proteins - metabolism DNA Transposable Elements - genetics Drosophila Proteins - metabolism Epigenesis, Genetic Gene Silencing Histones - chemistry Histones - metabolism Internal Medicine RNA, Small Interfering - genetics RNA, Small Interfering - metabolism
Online-Zugang:	Volltext
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Zusammenfassung:	Piwi-interacting RNAs (piRNAs) were reported in 2006 as a novel class of small non-coding RNAs associated with Piwi proteins of the Argonaute/Piwi family. Recent studies have revealed not only the biogenesis of piRNAs and their roles in transposon silencing, but also the function of the Piwi-piRNA pathway in epigenetic and post-transcriptional regulation of gene expression. In addition, the function of this pathway in somatic cells has also been more systematically characterized. The new findings reveal the Piwi-piRNA pathway as a more general mechanism of gene regulation.
ISSN:	0955-0674 1879-0410
DOI:	10.1016/j.ceb.2013.01.010