Cellular Defense System Gene Expression Profiling of Human Whole Blood: Opportunities to Predict Health Benefits in Response to Diet
Diet is a critical factor in the maintenance of human cellular defense systems, immunity, inflammation, redox regulation, metabolism, and DNA repair that ensure optimal health and reduce disease risk. Assessment of dietary modulation of cellular defense systems in humans has been limited due to diff...
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Veröffentlicht in: | Advances in nutrition (Bethesda, Md.) Md.), 2012-07, Vol.3 (4), p.499-505 |
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description | Diet is a critical factor in the maintenance of human cellular defense systems, immunity, inflammation, redox regulation, metabolism, and DNA repair that ensure optimal health and reduce disease risk. Assessment of dietary modulation of cellular defense systems in humans has been limited due to difficulties in accessing target tissues. Notably, peripheral blood gene expression profiles associated with nonhematologic disease are detectable. Coupled with recent innovations in gene expression technologies, gene expression profiling of human blood to determine predictive markers associated with health status and dietary modulation is now a feasible prospect for nutrition scientists. This review focuses on cellular defense system gene expression profiling of human whole blood and the opportunities this presents, using recent technological advances, to predict health status and benefits conferred by diet. |
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This review focuses on cellular defense system gene expression profiling of human whole blood and the opportunities this presents, using recent technological advances, to predict health status and benefits conferred by diet.</description><identifier>ISSN: 2161-8313</identifier><identifier>EISSN: 2156-5376</identifier><identifier>DOI: 10.3945/an.112.002121</identifier><identifier>PMID: 22797985</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Blood Physiological Phenomena - genetics ; Diet ; Gene Expression ; Gene Expression Profiling - methods ; Genetic Predisposition to Disease ; Genetic Testing - methods ; Health Status ; Humans ; Immunity, Cellular - genetics ; Microarray Analysis ; Micronutrients ; Reviews ; RNA - analysis</subject><ispartof>Advances in nutrition (Bethesda, Md.), 2012-07, Vol.3 (4), p.499-505</ispartof><rights>2012 American Society for Nutrition</rights><rights>2012 American Society for Nutrition 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-26041cec155c89080166f6b1d8afc513bb6918b77dfb0f3e603eaaa2e791ecd73</citedby><cites>FETCH-LOGICAL-c435t-26041cec155c89080166f6b1d8afc513bb6918b77dfb0f3e603eaaa2e791ecd73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649718/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649718/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22797985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Drew, Janice E.</creatorcontrib><title>Cellular Defense System Gene Expression Profiling of Human Whole Blood: Opportunities to Predict Health Benefits in Response to Diet</title><title>Advances in nutrition (Bethesda, Md.)</title><addtitle>Adv Nutr</addtitle><description>Diet is a critical factor in the maintenance of human cellular defense systems, immunity, inflammation, redox regulation, metabolism, and DNA repair that ensure optimal health and reduce disease risk. 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source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
subjects | Blood Physiological Phenomena - genetics Diet Gene Expression Gene Expression Profiling - methods Genetic Predisposition to Disease Genetic Testing - methods Health Status Humans Immunity, Cellular - genetics Microarray Analysis Micronutrients Reviews RNA - analysis |
title | Cellular Defense System Gene Expression Profiling of Human Whole Blood: Opportunities to Predict Health Benefits in Response to Diet |
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