Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4

Aims/hypothesis Most genetic variants identified for type 2 diabetes have been discovered in European populations. We performed genome-wide association studies (GWAS) in a Chinese population with the aim of identifying novel variants for type 2 diabetes in Asians. Methods We performed a meta-analysi...

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Veröffentlicht in:	Diabetologia 2013-06, Vol.56 (6), p.1291-1305
Hauptverfasser:	Ma, R. C. W., Hu, C., Tam, C. H., Zhang, R., Kwan, P., Leung, T. F., Thomas, G. N., Go, M. J., Hara, K., Sim, X., Ho, J. S. K., Wang, C., Li, H., Lu, L., Wang, Y., Li, J. W., Lam, V. K. L., Wang, J., Yu, W., Kim, Y. J., Ng, D. P., Fujita, H., Panoutsopoulou, K., Day-Williams, A. G., Lee, H. M., Ng, A. C. W., Fang, Y-J., Kong, A. P. S., Jiang, F., Ma, X., Hou, X., Tang, S., Lu, J., Yamauchi, T., Tsui, S. K. W., Woo, J., Leung, P. C., Zhang, X., Tang, N. L. S., Sy, H. Y., Liu, J., Wong, T. Y., Lee, J. Y., Maeda, S., Xu, G., Cherny, S. S., Chan, T. F., Ng, M. C. Y., Xiang, K., Morris, A. P., Keildson, S., Hu, R., Ji, L., Lin, X., Cho, Y. S., Kadowaki, T., Tai, E. S., Zeggini, E., McCarthy, M. I., Hon, K. L., Baum, L., Tomlinson, B., So, W. Y., Bao, Y., Chan, J. C. N., Jia, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Asians Biological and medical sciences China Chromosomes, Human, Pair 7 Consortia Diabetes Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Genetic Markers Genetic Predisposition to Disease Genetic Variation Genetics Genome-Wide Association Study Genomes Genotype Homeodomain Proteins - genetics Hong Kong Hospitals Human Physiology Humans Insulin-Secreting Cells - cytology Internal Medicine Japan Life sciences Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolic disorders Middle Aged Paired Box Transcription Factors - genetics Pallets Public health Singapore
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Zusammenfassung:	Aims/hypothesis Most genetic variants identified for type 2 diabetes have been discovered in European populations. We performed genome-wide association studies (GWAS) in a Chinese population with the aim of identifying novel variants for type 2 diabetes in Asians. Methods We performed a meta-analysis of three GWAS comprising 684 patients with type 2 diabetes and 955 controls of Southern Han Chinese descent. We followed up the top signals in two independent Southern Han Chinese cohorts (totalling 10,383 cases and 6,974 controls), and performed in silico replication in multiple populations. Results We identified CDKN2A/B and four novel type 2 diabetes association signals with p
ISSN:	0012-186X 1432-0428
DOI:	10.1007/s00125-013-2874-4