Cancer Pharmacogenomics

Pharmacogenomics research is yielding molecular diagnostic tools that can be used to optimize the selection of medications and their doses for individual patients. Given the narrow therapeutic index of most anticancer agents and the serious consequences of undertreatment, cancer chemotherapy is a co...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2011-09, Vol.90 (3), p.461-466
Hauptverfasser:	Paugh, S W, Stocco, G, McCorkle, J R, Diouf, B, Crews, K R, Evans, W E
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Genome, Human Humans Medical sciences Neoplasms - drug therapy Neoplasms - genetics Pharmacogenetics Pharmacology. Drug treatments Precision Medicine Treatment Outcome
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Beschreibung
Zusammenfassung:	Pharmacogenomics research is yielding molecular diagnostic tools that can be used to optimize the selection of medications and their doses for individual patients. Given the narrow therapeutic index of most anticancer agents and the serious consequences of undertreatment, cancer chemotherapy is a compelling therapeutic area for translation of pharmacogenomics to the clinic. This review addresses how inherited (germline) and acquired (somatic) sources of genome variability can alter the toxicity or efficacy of cancer chemotherapy. Clinical Pharmacology & Therapeutics (2011) 90 3, 461–466. doi:10.1038/clpt.2011.126
ISSN:	0009-9236 1532-6535
DOI:	10.1038/clpt.2011.126