COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome

Abstract The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, exec...

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Veröffentlicht in:	Psychiatry research 2010-07, Vol.178 (2), p.433-436
Hauptverfasser:	Shashi, Vandana, Howard, Timothy D, Keshavan, Matcheri S, Kaczorowski, Jessica, Berry, Margaret N, Schoch, Kelly, Spence, Edward J, Kwapil, Thomas R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Anxiety - genetics Anxiety disorders Biological and medical sciences Catechol O-Methyltransferase - genetics Child Child clinical studies Cognition Disorders - genetics COMT Val/Met DiGeorge Syndrome - genetics Executive Function - physiology Female Genetic Predisposition to Disease Genotype Humans Male Medical sciences Methionine - genetics Neuropsychological Tests Polymorphism, Single Nucleotide Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology Psychopathology. Psychiatry Valine - genetics Velocardiofacial syndrome
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Zusammenfassung:	Abstract The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.
ISSN:	0165-1781 1872-7123
DOI:	10.1016/j.psychres.2010.04.048