The Relation between Renal Function and Serum Sclerostin in Adult Patients with CKD

The Relation between Renal Function and Serum Sclerostin in Adult Patients with CKD

Sclerostin, a bone antianabolic peptide involved in osteoporosis, is elevated in patients undergoing maintenance dialysis. However, there are no data for patients with early CKD. Between January and July 2010, serum sclerostin and GFR (calculated by inulin clearance) were measured in 90 patients wit...

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Veröffentlicht in:Clinical journal of the American Society of Nephrology 2013-05, Vol.8 (5), p.819-823
Hauptverfasser: Pelletier, Solenne, Dubourg, Laurence, Carlier, Marie-Christine, Hadj-Aissa, Aoumeur, Fouque, Denis
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Biomarkers - blood
Bone Morphogenetic Proteins - blood
Case-Control Studies
Cross-Sectional Studies
Female
Genetic Markers
Glomerular Filtration Rate
Humans
Kidney - physiopathology
Male
Middle Aged
Multivariate Analysis
Original
Phosphates - blood
Prognosis
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - physiopathology
Sex Factors
Up-Regulation
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Zusammenfassung:Sclerostin, a bone antianabolic peptide involved in osteoporosis, is elevated in patients undergoing maintenance dialysis. However, there are no data for patients with early CKD. Between January and July 2010, serum sclerostin and GFR (calculated by inulin clearance) were measured in 90 patients with CKD. Fasting blood samples were also drawn for determination of calcium, phosphorus, parathyroid hormone, bone alkaline phosphatase, and 25-OH vitamin D. Median GFR was 66.5 (interquartile range, 40.0-88.3) ml/min per 1.73 m(2). Median sclerostin level was 53.5 (interquartile range, 37.5-77.2) pmol/L, was higher in patients with a GFR
ISSN:1555-9041
1555-905X
DOI:10.2215/CJN.07670712