PGE2 suppresses NK activity in vivo directly and through adrenal hormones: Effects that cannot be reflected by ex vivo assessment of NK cytotoxicity

Highlight ► This study exemplifies the limitations of the ex vivo approach in reflecting short term effects of some stress factors on NK activity.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2013-02, Vol.28, p.128-138
Hauptverfasser:	Meron, G, Tishler, Y, Shaashua, L, Rosenne, E, Levi, B, Melamed, R, Gotlieb, N, Matzner, P, Sorski, L, Ben-Eliyahu, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - physiology Adrenalectomy Allergy and Immunology Animals Catecholamines Cell Line, Tumor Cytotoxicity Dinoprostone - physiology Epinephrine Epinephrine - pharmacology Ex vivo Female Flow Cytometry Glucocorticoids Glucocorticoids - pharmacology Hormones In vitro In vivo Inflammation Intravenous administration Killer Cells, Natural - drug effects Killer Cells, Natural - physiology Kinetics Laparotomy - adverse effects Male Natural killer cells NK activity Prostaglandin E2 Prostaglandins Psychiatry Rats Rats, Inbred F344 Surgery Tumors
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Highlight ► This study exemplifies the limitations of the ex vivo approach in reflecting short term effects of some stress factors on NK activity.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2012.11.003