Short-term exercise increases GDNF protein levels in the spinal cord of young and old rats

Highlights • Exercise increases GDNF protein content in the spinal cord. • Low-intensity, forced running elicits the greatest fold-change in GDNF content. • Motor neuron cell body size increases over the same time course as GDNF protein. • Molecular weight of GDNF protein in the spinal cord changes...

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Veröffentlicht in:	Neuroscience 2013-06, Vol.240, p.258-268
Hauptverfasser:	McCullough, M.J, Gyorkos, A.M, Spitsbergen, J.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors aging Analysis of Variance Animals Autoantigens - metabolism Biological and medical sciences Disease Models, Animal exercise Fundamental and applied biological sciences. Psychology GDNF Gene Expression Regulation - physiology Glial Cell Line-Derived Neurotrophic Factor - metabolism Locomotion Male Membrane Proteins - metabolism motor neuron Motor Neurons - metabolism Motor Neurons - pathology Nerve Growth Factors - metabolism neural plasticity Neurology Physical Conditioning, Animal - methods Rats Rats, Sprague-Dawley spinal cord Spinal Cord - metabolism Spinal Cord - pathology Spinal Cord Injuries - pathology Spinal Cord Injuries - rehabilitation Swimming Time Factors Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • Exercise increases GDNF protein content in the spinal cord. • Low-intensity, forced running elicits the greatest fold-change in GDNF content. • Motor neuron cell body size increases over the same time course as GDNF protein. • Molecular weight of GDNF protein in the spinal cord changes with advancing age. • Exercise increases GDNF staining in and around motor neurons in the spinal cord.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.02.063