Identification of small RNAs associated with meiotic silencing by unpaired DNA

In Neurospora crassa, unpaired genes are silenced by a mechanism called meiotic silencing by unpaired DNA (MSUD). Although some RNA interference proteins are necessary for this process, its requirement of small RNAs has yet to be formally established. Here we report the characterization of small RNA...

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Veröffentlicht in:	Genetics (Austin) 2013-05, Vol.194 (1), p.279-284
Hauptverfasser:	Hammond, Thomas M, Spollen, William G, Decker, Logan M, Blake, Sean M, Springer, Gordon K, Shiu, Patrick K T
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Cell division Crosses, Genetic Deoxyribonucleic acid DNA DNA, Fungal - metabolism Exons - genetics Fungi GC Rich Sequence - genetics Gene Silencing Genes, Fungal Genetic Loci - genetics Introns - genetics Meiosis - genetics Neurospora crassa Neurospora crassa - cytology Neurospora crassa - genetics Nucleotides - genetics Reproducibility of Results Ribonucleic acid RNA RNA, Fungal - metabolism RNA, Small Interfering - metabolism Spores, Fungal - genetics
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Zusammenfassung:	In Neurospora crassa, unpaired genes are silenced by a mechanism called meiotic silencing by unpaired DNA (MSUD). Although some RNA interference proteins are necessary for this process, its requirement of small RNAs has yet to be formally established. Here we report the characterization of small RNAs targeting an unpaired region, using Illumina sequencing.
ISSN:	1943-2631 0016-6731 1943-2631
DOI:	10.1534/genetics.112.149138