LKB1 and AMPK and the cancer-metabolism link - ten years after

The identification of a complex containing the tumor suppressor LKB1 as the critical upstream kinase required for the activation of AMP-activated protein kinase (AMPK) by metabolic stress was reported in an article in Journal of Biology in 2003. This finding represented the first clear link between...

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Veröffentlicht in:	BMC biology 2013-04, Vol.11 (1), p.36-36, Article 36
Hauptverfasser:	Hardie, D Grahame, Alessi, Dario R
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism Cancer Cell Transformation, Neoplastic - pathology Colleges & universities Energy Metabolism Enzymes Genetic aspects Health aspects Humans Kinases Medical research Neoplasms - enzymology Neoplasms - metabolism Neoplasms - prevention & control Neoplasms - therapy Physiological aspects Protein kinases Protein Serine-Threonine Kinases - metabolism Proteins Review Signal Transduction Tumor suppressor genes
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Beschreibung
Zusammenfassung:	The identification of a complex containing the tumor suppressor LKB1 as the critical upstream kinase required for the activation of AMP-activated protein kinase (AMPK) by metabolic stress was reported in an article in Journal of Biology in 2003. This finding represented the first clear link between AMPK and cancer. Here we briefly discuss how this discovery came about, and describe some of the insights, especially into the role of AMPK in cancer, that have followed from it.
ISSN:	1741-7007 1741-7007
DOI:	10.1186/1741-7007-11-36