Abyssomicin Biosynthesis: Formation of an Unusual Polyketide, Antibiotic-Feeding Studies and Genetic Analysis

Small wonder: Atrop‐abyssomicin C is a small, yet complex spirotetronate (see scheme) that is active against Gram‐positive bacteria, such as MRSA. Feeding studies and genetic manipulation of its producer, Verrucosispora maris AB‐18‐032, for the first time give insight into its biosynthesis and demon...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2011-06, Vol.12 (9), p.1401-1410
Hauptverfasser:	Gottardi, Elvira M., Krawczyk, Joanna M., von Suchodoletz, Hanna, Schadt, Simone, Mühlenweg, Agnes, Uguru, Gabriel C., Pelzer, Stefan, Fiedler, Hans-Peter, Bibb, Mervyn J., Stach, James E. M., Süssmuth, Roderich D.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminobenzoic Acid - antagonists & inhibitors Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - pharmacology antibiotics biosynthesis Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis Bridged Bicyclo Compounds, Heterocyclic - pharmacology Communications feeding studies gene clusters Macrolides - pharmacology Micromonosporaceae - genetics Micromonosporaceae - metabolism Multigene Family - genetics polyketides
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Zusammenfassung:	Small wonder: Atrop‐abyssomicin C is a small, yet complex spirotetronate (see scheme) that is active against Gram‐positive bacteria, such as MRSA. Feeding studies and genetic manipulation of its producer, Verrucosispora maris AB‐18‐032, for the first time give insight into its biosynthesis and demonstrate how closely related the members of this important class of molecules are.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.201100172