Ambient particulate matter affects occludin distribution and increases alveolar transepithelial electrical conductance

ABSTRACT Background and objective: Inhaled particulate matter (PM) causes lung inflammation and epithelial dysfunction. However, the direct effect of PM on alveolar epithelial barrier integrity is not well understood. Our aim is to determine whether PM exposure affects the alveolar epithelial cells...

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Veröffentlicht in:	Respirology (Carlton, Vic.) Vic.), 2011-02, Vol.16 (2), p.340-349
Hauptverfasser:	CARABALLO, Juan C., YSHII, Cecilia, WESTPHAL, Whitney, MONINGER, Thomas, COMELLAS, Alejandro P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catalase - metabolism Cell Line Cell Membrane Permeability - drug effects Cell Membrane Permeability - physiology Cells, Cultured Dextrans Electric Conductivity Fluorescein-5-isothiocyanate - analogs & derivatives Humans Lanthanum Male Membrane Proteins - drug effects Membrane Proteins - physiology Occludin particulate matter Particulate Matter - pharmacology Phosphoproteins - drug effects Phosphoproteins - physiology pneumocyte Pulmonary Alveoli - drug effects Pulmonary Alveoli - enzymology Pulmonary Alveoli - physiology Rats Rats, Sprague-Dawley reactive oxygen species Superoxide Dismutase - metabolism Tight Junctions - drug effects Tight Junctions - physiology Titanium - metabolism Titanium - physiology Vehicle Emissions - analysis Zonula Occludens-1 Protein
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Zusammenfassung:	ABSTRACT Background and objective: Inhaled particulate matter (PM) causes lung inflammation and epithelial dysfunction. However, the direct effect of PM on alveolar epithelial barrier integrity is not well understood. Our aim is to determine whether PM exposure affects the alveolar epithelial cells (AEC) transepithelial electrical conductance (Gt) and tight junction (TJ) proteins. Methods: Human AEC (A549) and primary rat AEC were exposed to PM of
ISSN:	1323-7799 1440-1843
DOI:	10.1111/j.1440-1843.2010.01910.x