The ability of synovitis to predict structural damage in rheumatoid arthritis: a comparative study between clinical examination and ultrasound

Objectives To evaluate synovitis (clinical vs ultrasound (US)) to predict structural progression in rheumatoid arthritis (RA). Methods Patients with RA. Study design Prospective, 2-year follow-up. Data collected Synovitis (32 joints (2 wrists, 10 metacarpophalangeal, 10 proximal interphalangeal, 10...

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Veröffentlicht in:Annals of the rheumatic diseases 2013-05, Vol.72 (5), p.665-671
Hauptverfasser: Dougados, Maxime, Devauchelle-Pensec, Valérie, Ferlet, Jean françois, Jousse-Joulin, sandrine, D'Agostino, Maria-Antonietta, Backhaus, Marina, Bentin, Jacques, Chalès, Gérard, Chary-Valckenaere, Isabelle, Conaghan, Philip, Wakefield, Richard J, Etcheparre, Frédéric, Gaudin, Philippe, Grassi, Walter, Heijde, Désirée van der, Mariette, Xavier, Naredo, Esperanza, Szkudlarek, Marcin
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Sprache:eng
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Zusammenfassung:Objectives To evaluate synovitis (clinical vs ultrasound (US)) to predict structural progression in rheumatoid arthritis (RA). Methods Patients with RA. Study design Prospective, 2-year follow-up. Data collected Synovitis (32 joints (2 wrists, 10 metacarpophalangeal, 10 proximal interphalangeal, 10 metatarsophalangeal)) at baseline and after 4 months of therapy by clinical, US grey scale (GS-US) and power doppler (PD-US); x-rays at baseline and at year 2. Analysis Measures of association (OR) were tested between structural deterioration and the presence of baseline synovitis, or its persistence, after 4 months of therapy using generalised estimating equation analysis. Results Structural deterioration was observed in 9% of the 1888 evaluated joints in 59 patients. Baseline synovitis increased the risk of structural progression: OR=2.01 (1.36–2.98) p
ISSN:0003-4967
1468-2060
DOI:10.1136/annrheumdis-2012-201469