Photocontrolled Binding and Binding-Controlled Photochromism within Anthracene-Modified DNA

Photocontrolled Binding and Binding-Controlled Photochromism within Anthracene-Modified DNA

Modified DNA strands undergo a reversible light-induced reaction involving the intramolecular photodimerization of two appended anthracene tags. The photodimers exhibit markedly different binding behavior toward a complementary strand that depends on the number of bases between the modified position...

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Veröffentlicht in:Journal of the American Chemical Society 2012-07, Vol.134 (26), p.10791-10794
Hauptverfasser: Manchester, Jack, Bassani, Dario M., Duprey, Jean-Louis H. A., Giordano, Luciana, Vyle, Joseph S., Zhao, Zheng-yun, Tucker, James H. R.
Format: Artikel
Sprache:eng
Schlagworte:
Anthracenes - chemistry
Anthracenes - radiation effects
Base Sequence
Communication
DNA - chemistry
DNA - radiation effects
Light
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Zusammenfassung:Modified DNA strands undergo a reversible light-induced reaction involving the intramolecular photodimerization of two appended anthracene tags. The photodimers exhibit markedly different binding behavior toward a complementary strand that depends on the number of bases between the modified positions. By preforming the duplex, photochromism can be suppressed, illustrating dual-mode gated behavior.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja304205m