Stem Cell Therapy for Lower Extremity Diabetic Ulcers: Where Do We Stand?
The impairment of wound healing in diabetic patients is an important clinical problem affecting millions of patients worldwide. Various clinical and basic science studies show that stem cell therapy, as a regenerative medical therapy, can be a good solution. In this paper, we begin with an introduct...
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| Veröffentlicht in: | BioMed research international 2013-01, Vol.2013 (2013), p.1-8 |
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| creator | Li, Qingfeng Zhang, Tian R. Sheng, Lingling Yang, Mei |
| description | The impairment of wound healing in diabetic patients is an important clinical problem affecting millions of patients worldwide. Various clinical and basic science studies show that stem cell therapy, as a regenerative medical therapy, can be a good solution. In this paper, we begin with an introduction of the cellular mechanism of the diabetic ulcer. We will then discuss the advantages and limitations of various stem cell therapies that have been under extensive recent study. |
| doi_str_mv | 10.1155/2013/462179 |
| format | Article |
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Various clinical and basic science studies show that stem cell therapy, as a regenerative medical therapy, can be a good solution. In this paper, we begin with an introduction of the cellular mechanism of the diabetic ulcer. We will then discuss the advantages and limitations of various stem cell therapies that have been under extensive recent study.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2013/462179</identifier><identifier>PMID: 23586040</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Care and treatment ; Cell- and Tissue-Based Therapy ; Diabetes Complications - complications ; Diabetes Complications - pathology ; Diabetes Complications - therapy ; Diabetic Foot - complications ; Diabetic Foot - pathology ; Diabetic Foot - therapy ; Diabetic ulcers ; Diagnosis ; Humans ; Lower Extremity - pathology ; Neovascularization, Physiologic ; Review ; Stem Cell Transplantation ; Stem cells ; Transplantation ; Wound Healing</subject><ispartof>BioMed research international, 2013-01, Vol.2013 (2013), p.1-8</ispartof><rights>Copyright © 2013 Mei Yang et al.</rights><rights>COPYRIGHT 2013 John Wiley & Sons, Inc.</rights><rights>Copyright © 2013 Mei Yang et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-f2f52d4fcb82f9b90e903ea42feb86a1a646c9b05f9e5844a7250164e8cce99f3</citedby><cites>FETCH-LOGICAL-c566t-f2f52d4fcb82f9b90e903ea42feb86a1a646c9b05f9e5844a7250164e8cce99f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613085/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613085/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23586040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Gomer, Richard</contributor><creatorcontrib>Li, Qingfeng</creatorcontrib><creatorcontrib>Zhang, Tian R.</creatorcontrib><creatorcontrib>Sheng, Lingling</creatorcontrib><creatorcontrib>Yang, Mei</creatorcontrib><title>Stem Cell Therapy for Lower Extremity Diabetic Ulcers: Where Do We Stand?</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>The impairment of wound healing in diabetic patients is an important clinical problem affecting millions of patients worldwide. Various clinical and basic science studies show that stem cell therapy, as a regenerative medical therapy, can be a good solution. In this paper, we begin with an introduction of the cellular mechanism of the diabetic ulcer. We will then discuss the advantages and limitations of various stem cell therapies that have been under extensive recent study.</description><subject>Care and treatment</subject><subject>Cell- and Tissue-Based Therapy</subject><subject>Diabetes Complications - complications</subject><subject>Diabetes Complications - pathology</subject><subject>Diabetes Complications - therapy</subject><subject>Diabetic Foot - complications</subject><subject>Diabetic Foot - pathology</subject><subject>Diabetic Foot - therapy</subject><subject>Diabetic ulcers</subject><subject>Diagnosis</subject><subject>Humans</subject><subject>Lower Extremity - pathology</subject><subject>Neovascularization, Physiologic</subject><subject>Review</subject><subject>Stem Cell Transplantation</subject><subject>Stem cells</subject><subject>Transplantation</subject><subject>Wound Healing</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqN0c1LHDEYBvBQLFWsp95LwItUtuZ7Jh4sstpWWPCg4jFksm_clJnJmszW7n9vltHFntpcEsiPJx8PQp8o-UqplCeMUH4iFKOVfof2GKdioqigO9s157voIOdfpIyaKqLVB7TLuKwVEWQPXd0M0OEptC2-XUCyyzX2MeFZfIKEL_8MCbowrPFFsA0MweG71kHKp_i-YMAXEd8DvhlsP__2Eb33ts1w8DLvo7vvl7fTn5PZ9Y-r6fls4qRSw8QzL9lceNfUzOtGE9CEgxXMQ1MrS60SyumGSK9B1kLYiklClYDaOdDa8310NuYuV00Hcwf9kGxrlil0Nq1NtMH8vdOHhXmIvw0vn0FqWQKOXgJSfFxBHkwXsis_YHuIq2yo4JoxVXHxb8pZVTFFmC70cKQPtgUTeh_L4W7DzTmvOK9YLVlRx6NyKeacwG_vTYnZFGo2hZqx0KI_v33q1r7WV8CXESxCP7dP4f_SoBDw9g0mgkvKnwFVKq8Q</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Li, Qingfeng</creator><creator>Zhang, Tian R.</creator><creator>Sheng, Lingling</creator><creator>Yang, Mei</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>Stem Cell Therapy for Lower Extremity Diabetic Ulcers: Where Do We Stand?</title><author>Li, Qingfeng ; Zhang, Tian R. ; Sheng, Lingling ; Yang, Mei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-f2f52d4fcb82f9b90e903ea42feb86a1a646c9b05f9e5844a7250164e8cce99f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Care and treatment</topic><topic>Cell- and Tissue-Based Therapy</topic><topic>Diabetes Complications - complications</topic><topic>Diabetes Complications - pathology</topic><topic>Diabetes Complications - therapy</topic><topic>Diabetic Foot - complications</topic><topic>Diabetic Foot - pathology</topic><topic>Diabetic Foot - therapy</topic><topic>Diabetic ulcers</topic><topic>Diagnosis</topic><topic>Humans</topic><topic>Lower Extremity - pathology</topic><topic>Neovascularization, Physiologic</topic><topic>Review</topic><topic>Stem Cell Transplantation</topic><topic>Stem cells</topic><topic>Transplantation</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Qingfeng</creatorcontrib><creatorcontrib>Zhang, Tian R.</creatorcontrib><creatorcontrib>Sheng, Lingling</creatorcontrib><creatorcontrib>Yang, Mei</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Qingfeng</au><au>Zhang, Tian R.</au><au>Sheng, Lingling</au><au>Yang, Mei</au><au>Gomer, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stem Cell Therapy for Lower Extremity Diabetic Ulcers: Where Do We Stand?</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>2013</volume><issue>2013</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>The impairment of wound healing in diabetic patients is an important clinical problem affecting millions of patients worldwide. Various clinical and basic science studies show that stem cell therapy, as a regenerative medical therapy, can be a good solution. In this paper, we begin with an introduction of the cellular mechanism of the diabetic ulcer. We will then discuss the advantages and limitations of various stem cell therapies that have been under extensive recent study.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>23586040</pmid><doi>10.1155/2013/462179</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2314-6133 |
| ispartof | BioMed research international, 2013-01, Vol.2013 (2013), p.1-8 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Care and treatment Cell- and Tissue-Based Therapy Diabetes Complications - complications Diabetes Complications - pathology Diabetes Complications - therapy Diabetic Foot - complications Diabetic Foot - pathology Diabetic Foot - therapy Diabetic ulcers Diagnosis Humans Lower Extremity - pathology Neovascularization, Physiologic Review Stem Cell Transplantation Stem cells Transplantation Wound Healing |
| title | Stem Cell Therapy for Lower Extremity Diabetic Ulcers: Where Do We Stand? |
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