A Randomized, Double-Blind Placebo Controlled Trial of Balapiravir, a Polymerase Inhibitor, in Adult Dengue Patients

Background. Dengue is the most common arboviral infection of humans. There are currently no specific treatments for dengue. Balapiravir is a prodrug of a nucleoside analogue (called R1479) and an inhibitor of hepatitis C virus replication in vivo. Methods. We conducted in vitro experiments to determ...

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Veröffentlicht in:	The Journal of infectious diseases 2013-05, Vol.207 (9), p.1442-1450
Hauptverfasser:	Nguyen, Nguyet Minh, Tran, Chau Nguyen Bich, Phung, Lam Khanh, Duong, Kien Thi Hue, le Anh Huynh, Huy, Farrar, Jeremy, Nguyen, Quyen Than Ha, Tran, Hien Tinh, Van Vinh Nguyen, Chau, Merson, Laura, Hoang, Long Truong, Hibberd, Martin L., Aw, Pauline P. K., Wilm, Andreas, Nagarajan, Niranjan, Nguyen, Dung Thi, Pham, Mai Phuong, Nguyen, Truong Thanh, Javanbakht, Hassan, Klumpp, Klaus, Hammond, Janet, Petric, Rosemary, Wolbers, Marcel, Nguyen, Chinh Tran, Simmons, Cameron P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Antigens, Viral - blood Antiviral Agents - administration & dosage Antiviral Agents - adverse effects Antivirals Arboviroses Biological and medical sciences Blood plasma Dengue Dengue - drug therapy Dengue - pathology Dengue - virology Dengue fevers Dengue Virus - isolation & purification Dosage Double-Blind Method Fever - drug therapy Fundamental and applied biological sciences. Psychology Hepatitis C virus Human viral diseases Humans Infections Infectious diseases Major and Brief Reports Male Medical sciences Microbiology Nucleosides - administration & dosage Nucleosides - adverse effects Placebos Placebos - administration & dosage Statistical median Treatment Outcome Tropical viral diseases Viral diseases Viral Load Viremia Viremia - drug therapy Virology Viruses Young Adult
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Zusammenfassung:	Background. Dengue is the most common arboviral infection of humans. There are currently no specific treatments for dengue. Balapiravir is a prodrug of a nucleoside analogue (called R1479) and an inhibitor of hepatitis C virus replication in vivo. Methods. We conducted in vitro experiments to determine the potency of balapiravir against dengue viruses and then an exploratory, dose-escalating, randomized placebo-controlled trial in adult male patients with dengue with
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/jis470