Type 2 diabetes: etiology and reversibility

Insulin resistance may be caused by an insulin signaling defect (5), glucose transporter defect (6), or lipotoxicity (7), and ß-cell dysfunction is postulated to be caused by amyloid deposition in the islets (8), oxidative stress (9), excess fatty acid (10), or lack of incretin effect (11). Fasting...

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Veröffentlicht in:	Diabetes care 2013-04, Vol.36 (4), p.1047-1055
1. Verfasser:	Taylor, Roy
Format:	Artikel
Sprache:	eng
Schlagworte:	Bariatric Surgery Causes and theories of causation Development and progression Dextrose Diabetes Diabetes Mellitus, Type 2 - diet therapy Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - surgery Diet Diseases Glucose Glucose metabolism Humans Hyperglycemia Insulin Insulin resistance Insulin Resistance - physiology Metabolism Obesity Review Surgery Type 2 diabetes Weight control
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Zusammenfassung:	Insulin resistance may be caused by an insulin signaling defect (5), glucose transporter defect (6), or lipotoxicity (7), and ß-cell dysfunction is postulated to be caused by amyloid deposition in the islets (8), oxidative stress (9), excess fatty acid (10), or lack of incretin effect (11). Fasting plasma glucose was shown to be improved because of an 81% decrease in liver fat content and normalization of hepatic insulin sensitivity with no change in the insulin resistance of muscle.
ISSN:	0149-5992 1935-5548
DOI:	10.2337/dc12-1805