DCCT and EDIC Studies in Type 1 Diabetes: Lessons for Diabetic Neuropathy Regarding Metabolic Memory and Natural History

The DCCT/EDIC (Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications) provides a comprehensive characterization of the natural history of diabetic neuropathy in patients with type 1 diabetes and provides insight into the impact of intensive insulin therap...

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Veröffentlicht in:	Current diabetes reports 2010-08, Vol.10 (4), p.276-282
Hauptverfasser:	Pop-Busui, Rodica, Herman, William H., Feldman, Eva L., Low, Phillip A., Martin, Catherine L., Cleary, Patricia A., Waberski, Barbara H., Lachin, John M., Albers, James W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Autonomic Nervous System Diseases - etiology Autonomic Nervous System Diseases - therapy Cardiomyopathies - etiology Cardiomyopathies - therapy Diabetes Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - therapy Diabetic Neuropathies - etiology Diabetic Neuropathies - metabolism Female Humans Hypoglycemic Agents - therapeutic use Insulin - therapeutic use Male Medicine Medicine & Public Health Randomized Controlled Trials as Topic
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Zusammenfassung:	The DCCT/EDIC (Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications) provides a comprehensive characterization of the natural history of diabetic neuropathy in patients with type 1 diabetes and provides insight into the impact of intensive insulin therapy in disease progression. The lessons learned about the natural history of distal symmetrical polyneuropathy and cardiovascular autonomic neuropathy and the impact of glycemic control on neuropathy are discussed in this review.
ISSN:	1534-4827 1539-0829
DOI:	10.1007/s11892-010-0120-8