The relation of developmental changes in brain serotonin transporter (5HTT) and 5HT1A receptor binding to emotional behavior in female rhesus monkeys: Effects of social status and 5HTT genotype

Highlights ► 5HT1A and 5HTT BP increased in female rhesus brain regions through puberty. ► Hypothalamic 5HT1A receptor binding was increased in subordinate juvenile females. ► Higher orbitofrontal cortex 5HTT BP was detected in subordinate females. ► No main effects of 5HTT genotype were observed fo...

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Veröffentlicht in:	Neuroscience 2013-01, Vol.228, p.83-100
Hauptverfasser:	Embree, M, Michopoulos, V, Votaw, J.R, Voll, R.J, Mun, J, Stehouwer, J.S, Goodman, M.M, Wilson, M.E, Sánchez, M.M
Format:	Artikel
Sprache:	eng
Schlagworte:	[18F]FEmZIENT Animals Behavioral psychophysiology Biological and medical sciences Brain - growth & development Brain - metabolism Emotions - physiology Female Fundamental and applied biological sciences. Psychology Genotype Humans Macaca mulatta Neurology Neurotransmission and behavior nonhuman primates p-[18F]MPPF Protein Binding - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Receptor, Serotonin, 5-HT1A - metabolism Serotonin Plasma Membrane Transport Proteins - genetics Serotonin Plasma Membrane Transport Proteins - metabolism serotonin transporter polymorphisms Social Behavior social stress
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Zusammenfassung:	Highlights ► 5HT1A and 5HTT BP increased in female rhesus brain regions through puberty. ► Hypothalamic 5HT1A receptor binding was increased in subordinate juvenile females. ► Higher orbitofrontal cortex 5HTT BP was detected in subordinate females. ► No main effects of 5HTT genotype were observed for 5HT1A or 5HTT BP. ► Developmental changes in 5HT systems related to different behavioral reactivity.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.10.016