Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression

Parkinson's disease (PD) is the second most common neurodegenerative disorder in the developed world, and is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra (SN). Somatic mitochondrial DNA (mtDNA) deletions reach their highest concentration with age in the SN in h...

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Veröffentlicht in:	Human molecular genetics 2012-12, Vol.21 (23), p.5147-5158
Hauptverfasser:	LANYING SONG, YUXI SHAN, KENT LLOYD, K. C, CORTOPASSI, Gino A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy - genetics Behavior, Animal Biological and medical sciences Cell Line Cell physiology Cell Respiration - genetics Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes DNA Helicases - genetics DNA Helicases - metabolism DNA, Mitochondrial - genetics Dopaminergic Neurons - metabolism Dopaminergic Neurons - pathology Fundamental and applied biological sciences. Psychology Gene Expression Gene Order Gene Targeting Genetics of eukaryotes. Biological and molecular evolution Humans Mice Mice, Transgenic Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Molecular and cellular biology Mutation Parkinson Disease - genetics Parkinson Disease - metabolism Promoter Regions, Genetic Proteasome Endopeptidase Complex - metabolism Protein Binding Substantia Nigra - metabolism Substantia Nigra - pathology Tyrosine 3-Monooxygenase - genetics Tyrosine 3-Monooxygenase - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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