Low-molecular-weight lipoprotein (a) and low relative lymphocyte concentration are significant and independent risk factors for coronary heart disease in patients with type 2 diabetes mellitus: Lp(a) phenotype, lymphocyte, and coronary heart disease

The aim of the present prospective study was to examine whether lipoprotein (a) [Lp(a)] phenotypes and/or low relative lymphocyte concentration (LRLC) are independently associated with coronary heart disease (CHD) in patients with type 2 diabetes mellitus (T2DM). Serum Lp(a) concentration, Lp(a) phe...

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Veröffentlicht in:	Lipids in health and disease 2013-03, Vol.12 (1), p.31-31, Article 31
Hauptverfasser:	Suzuki, Tatsuya, Futami-Suda, Shoko, Igari, Yoshimasa, Watanabe, Kentaro, Ouchi, Motoshi, Suzuki, Kazunari, Sekimizu, Ken-Ichi, Kigawa, Yoshiaki, Nakano, Hiroshi, Oba, Kenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angina Angina pectoris Biomarkers - blood Cardiovascular disease Cholesterol Coronary Disease - blood Coronary Disease - diagnosis Coronary Disease - etiology Coronary Disease - pathology Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - pathology Drug therapy Electrophoresis, Polyacrylamide Gel Female Heart attacks Humans Lipoprotein(a) - blood Lipoprotein(a) - classification Lymphocyte Count Lymphocytes - pathology Male Middle Aged Molecular Weight Neutrophils - pathology Phenotype Prognosis Prospective Studies Risk Factors
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Zusammenfassung:	The aim of the present prospective study was to examine whether lipoprotein (a) [Lp(a)] phenotypes and/or low relative lymphocyte concentration (LRLC) are independently associated with coronary heart disease (CHD) in patients with type 2 diabetes mellitus (T2DM). Serum Lp(a) concentration, Lp(a) phenotypes, and RLC were analyzed in 214 subjects. Lp(a) phenotypes were classified into 7 subtypes according to sodium dodecyl sulfate-agarose gel electrophoresis by Western blotting. Subjects were assigned to the low-molecular-weight (LMW (number of KIV repeats: 11-22) ) and high-molecular-weight (HMW( number of KIV repeats: >22 )) Lp(a) groups according to Lp(a) phenotype and to the LRLC (RLC:
ISSN:	1476-511X 1476-511X
DOI:	10.1186/1476-511X-12-31