Dietary selenium fails to influence cigarette smoke-induced lung tumorigenesis in A/J mice

Highlights • Higher dietary sodium selenite did not inhibit the induction of lung tumors. • Higher dietary selenium increased selenium and GPx protein levels in the lung. • Dietary selenium did not affect lung SOD levels.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2013-06, Vol.334 (1), p.127-132
Hauptverfasser:	Glauert, Howard P, Martin, Joshua B, Li, Jun, Tharappel, Job C, Han, Sung Gu, Gillespie, Harold D, Cantor, Austin H, Lee, Eun Y, Gary Gairola, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticarcinogenic Agents - pharmacology Antioxidant Carcinogenesis Cigarette smoke Cigarettes Diet Dietary Supplements Female Glutathione Peroxidase - metabolism Hematology, Oncology and Palliative Medicine Lung Lung - drug effects Lung - metabolism Lung cancer Lung Neoplasms - chemically induced Lung Neoplasms - metabolism Lung Neoplasms - prevention & control Mice, Inbred Strains Proliferating Cell Nuclear Antigen - metabolism Proteins Rodents Selenium Selenium - pharmacology Software Studies Superoxide Dismutase - metabolism Tobacco smoke Tobacco Smoke Pollution - adverse effects Tumorigenesis Tumors Variance analysis Vitamin E
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Beschreibung
Zusammenfassung:	Highlights • Higher dietary sodium selenite did not inhibit the induction of lung tumors. • Higher dietary selenium increased selenium and GPx protein levels in the lung. • Dietary selenium did not affect lung SOD levels.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2012.11.047