Central α-adrenoceptors contribute to mustard oil-induced central sensitization in the rat medullary dorsal horn

Highlights ► Mustard oil (MO) induced central sensitization of NS neurons in MDH. ► Guanethidine and phentolamine blocked the MO-induced central sensitization. ► Prazosin significantly attenuated the MO-induced central sensitization. ► Yohimbine facilitated the responses of sensitized NS neurons. ►...

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Veröffentlicht in:	Neuroscience 2013-04, Vol.236, p.244-252
Hauptverfasser:	Wang, H, Xie, Y.F, Chiang, C.Y, Dostrovsky, J.O, Sessle, B.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Central Nervous System Sensitization - physiology Electrophysiology Fundamental and applied biological sciences. Psychology guanethidine Male Medulla Oblongata - metabolism Microelectrodes mustard oil Mustard Plant - toxicity Neurology phentolamine Plant Oils - toxicity prazosin Rats Rats, Sprague-Dawley Receptors, Adrenergic - metabolism tooth pulp Vertebrates: nervous system and sense organs yohimbine
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Zusammenfassung:	Highlights ► Mustard oil (MO) induced central sensitization of NS neurons in MDH. ► Guanethidine and phentolamine blocked the MO-induced central sensitization. ► Prazosin significantly attenuated the MO-induced central sensitization. ► Yohimbine facilitated the responses of sensitized NS neurons. ► α1 and α2-adrenoceptors are differentially involved in MDH central sensitization.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.01.016