A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations
Background IgE is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino subjects have not been well represented in genetic studies of total IgE. Objective We sought to identify the genetic predictors...
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| creator | Levin, Albert M., PhD Mathias, Rasika A., ScD Huang, Lili, MPH Roth, Lindsey A., MA Daley, Denise, PhD Myers, Rachel A., PhD Himes, Blanca E., PhD Romieu, Isabelle, MD, ScD Yang, Mao, MS Eng, Celeste, BS Park, Julie E., MMath Zoratti, Karla Gignoux, Christopher R., MS Torgerson, Dara G., PhD Galanter, Joshua M., MD Huntsman, Scott, MS Nguyen, Elizabeth A., BS Becker, Allan B., MD Chan-Yeung, Moira, MD Kozyrskyj, Anita L., PhD Kwok, Pui-Yan, MD, PhD Gilliland, Frank D., MD, PhD Gauderman, W. James, PhD Bleecker, Eugene R., MD Raby, Benjamin A., MD, MPH Meyers, Deborah A., PhD London, Stephanie J., MD, DrPH Martinez, Fernando D., MD Weiss, Scott T., MD, MS Burchard, Esteban G., MD, MPH Nicolae, Dan L., PhD Ober, Carole, PhD Barnes, Kathleen C., PhD Williams, L. Keoki, MD, MPH |
| description | Background IgE is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino subjects have not been well represented in genetic studies of total IgE. Objective We sought to identify the genetic predictors of serum total IgE levels. Methods We used genome-wide association data from 4292 subjects (2469 African Americans, 1564 European Americans, and 259 Latinos) in the EVE Asthma Genetics Consortium. Tests for association were performed within each cohort by race-ethnic group (ie, African American, Latino, and European American) and asthma status. The resulting P values were meta-analyzed, accounting for sample size and direction of effect. Top single nucleotide polymorphism associations from the meta-analysis were reassessed in 6 additional cohorts comprising 5767 subjects. Results We identified 10 unique regions in which the combined association statistic was associated with total serum IgE levels ( P |
| doi_str_mv | 10.1016/j.jaci.2012.10.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3596497</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0091674912016090</els_id><sourcerecordid>1560108483</sourcerecordid><originalsourceid>FETCH-LOGICAL-c700t-ac481f386b9d501f728f181e542653ea785908b45fccb55aa931d0f8628722683</originalsourceid><addsrcrecordid>eNqFkk1v1DAQhiMEokvhD3BAllAlLln8ETu2hCpVVYFKlTgAZ8vrTBYvSbx4kkX773G6Sws9wMny-Jl3ZvxOUbxkdMkoU283y43zYckp4zmwpJQ_KhaMmrpUmsvHxYJSw0pVV-akeIa4ofkutHlanHDBKiU0WxT-gvQwutINrttjQBJbsoYh9lD-DA0Qhxh9cGOIA8FxagIgaWMiCGnqyRhH15Hr9RUJA2nCDhLCLbYn27iduts8fF48aV2H8OJ4nhZf3199ufxY3nz6cH15cVP6mtKxdL7SrBVarUwjKWtrrlumGciKKynA1VoaqleVbL1fSemcEayhrVZc15wrLU6L84Pudlr10HgYxuQ6u02hd2lvowv275chfLPruLNCGlWZOgu8OQqk-GMCHG0f0EPXuQHihJZJRRnVlRb_RwXntZjNyOjrB-gmTin_9ywoZc0qU8lM8QPlU0RM0N71zaid7bYbO9ttZ7vnWLY7J736c-K7lN_-ZuDsCDj0rmuTG3zAe67mMvc4V3934CD7swuQLPoAg4cmJPCjbWL4dx_nD9J9F4aQK36HPeD9vBa5pfbzvJjzXrIsoqih4heFb9zd</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1555714945</pqid></control><display><type>article</type><title>A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Levin, Albert M., PhD ; Mathias, Rasika A., ScD ; Huang, Lili, MPH ; Roth, Lindsey A., MA ; Daley, Denise, PhD ; Myers, Rachel A., PhD ; Himes, Blanca E., PhD ; Romieu, Isabelle, MD, ScD ; Yang, Mao, MS ; Eng, Celeste, BS ; Park, Julie E., MMath ; Zoratti, Karla ; Gignoux, Christopher R., MS ; Torgerson, Dara G., PhD ; Galanter, Joshua M., MD ; Huntsman, Scott, MS ; Nguyen, Elizabeth A., BS ; Becker, Allan B., MD ; Chan-Yeung, Moira, MD ; Kozyrskyj, Anita L., PhD ; Kwok, Pui-Yan, MD, PhD ; Gilliland, Frank D., MD, PhD ; Gauderman, W. James, PhD ; Bleecker, Eugene R., MD ; Raby, Benjamin A., MD, MPH ; Meyers, Deborah A., PhD ; London, Stephanie J., MD, DrPH ; Martinez, Fernando D., MD ; Weiss, Scott T., MD, MS ; Burchard, Esteban G., MD, MPH ; Nicolae, Dan L., PhD ; Ober, Carole, PhD ; Barnes, Kathleen C., PhD ; Williams, L. Keoki, MD, MPH</creator><creatorcontrib>Levin, Albert M., PhD ; Mathias, Rasika A., ScD ; Huang, Lili, MPH ; Roth, Lindsey A., MA ; Daley, Denise, PhD ; Myers, Rachel A., PhD ; Himes, Blanca E., PhD ; Romieu, Isabelle, MD, ScD ; Yang, Mao, MS ; Eng, Celeste, BS ; Park, Julie E., MMath ; Zoratti, Karla ; Gignoux, Christopher R., MS ; Torgerson, Dara G., PhD ; Galanter, Joshua M., MD ; Huntsman, Scott, MS ; Nguyen, Elizabeth A., BS ; Becker, Allan B., MD ; Chan-Yeung, Moira, MD ; Kozyrskyj, Anita L., PhD ; Kwok, Pui-Yan, MD, PhD ; Gilliland, Frank D., MD, PhD ; Gauderman, W. James, PhD ; Bleecker, Eugene R., MD ; Raby, Benjamin A., MD, MPH ; Meyers, Deborah A., PhD ; London, Stephanie J., MD, DrPH ; Martinez, Fernando D., MD ; Weiss, Scott T., MD, MS ; Burchard, Esteban G., MD, MPH ; Nicolae, Dan L., PhD ; Ober, Carole, PhD ; Barnes, Kathleen C., PhD ; Williams, L. Keoki, MD, MPH</creatorcontrib><description>Background IgE is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino subjects have not been well represented in genetic studies of total IgE. Objective We sought to identify the genetic predictors of serum total IgE levels. Methods We used genome-wide association data from 4292 subjects (2469 African Americans, 1564 European Americans, and 259 Latinos) in the EVE Asthma Genetics Consortium. Tests for association were performed within each cohort by race-ethnic group (ie, African American, Latino, and European American) and asthma status. The resulting P values were meta-analyzed, accounting for sample size and direction of effect. Top single nucleotide polymorphism associations from the meta-analysis were reassessed in 6 additional cohorts comprising 5767 subjects. Results We identified 10 unique regions in which the combined association statistic was associated with total serum IgE levels ( P < 5.0 × 10−6 ) and the minor allele frequency was 5% or greater in 2 or more population groups. Variant rs9469220, corresponding to HLA-DQB1 , was the single nucleotide polymorphism most significantly associated with serum total IgE levels when assessed in both the replication cohorts and the discovery and replication sets combined ( P = .007 and 2.45 × 10−7 , respectively). In addition, findings from earlier genome-wide association studies were also validated in the current meta-analysis. Conclusion This meta-analysis independently identified a variant near HLA-DQB1 as a predictor of total serum IgE levels in multiple race-ethnic groups. This study also extends and confirms the findings of earlier genome-wide association analyses in African American and Latino subjects.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2012.10.002</identifier><identifier>PMID: 23146381</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Adult ; African Americans ; Aged ; Aged, 80 and over ; Allergies ; Allergy and Immunology ; Asthma ; Asthma - blood ; Asthma - ethnology ; Asthma - genetics ; Asthma - immunology ; Biological and medical sciences ; Canada - epidemiology ; Case-Control Studies ; Child ; Child, Preschool ; Chronic obstructive pulmonary disease ; continental population groups ; Ethnicity ; European Continental Ancestry Group ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genetics ; Genome-Wide Association Study ; Genomes ; Hispanic Americans ; HLA-DQ beta-Chains - blood ; HLA-DQ beta-Chains - genetics ; HLA-DQ beta-Chains - immunology ; Humans ; Immunoglobulin E - blood ; Immunoglobulin E - genetics ; Immunoglobulin E - immunology ; Immunopathology ; Male ; Medical sciences ; Meta-analysis ; Middle Aged ; Polymorphism, Single Nucleotide ; Population ; race-ethnicity ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Studies ; total IgE ; United States - epidemiology</subject><ispartof>Journal of allergy and clinical immunology, 2013-04, Vol.131 (4), p.1176-1184</ispartof><rights>American Academy of Allergy, Asthma & Immunology</rights><rights>2012 American Academy of Allergy, Asthma & Immunology</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Apr 2013</rights><rights>2012 American Academy of Allergy, Asthma and Immunology. Published by Mosby, Inc. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c700t-ac481f386b9d501f728f181e542653ea785908b45fccb55aa931d0f8628722683</citedby><cites>FETCH-LOGICAL-c700t-ac481f386b9d501f728f181e542653ea785908b45fccb55aa931d0f8628722683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaci.2012.10.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27251095$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23146381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levin, Albert M., PhD</creatorcontrib><creatorcontrib>Mathias, Rasika A., ScD</creatorcontrib><creatorcontrib>Huang, Lili, MPH</creatorcontrib><creatorcontrib>Roth, Lindsey A., MA</creatorcontrib><creatorcontrib>Daley, Denise, PhD</creatorcontrib><creatorcontrib>Myers, Rachel A., PhD</creatorcontrib><creatorcontrib>Himes, Blanca E., PhD</creatorcontrib><creatorcontrib>Romieu, Isabelle, MD, ScD</creatorcontrib><creatorcontrib>Yang, Mao, MS</creatorcontrib><creatorcontrib>Eng, Celeste, BS</creatorcontrib><creatorcontrib>Park, Julie E., MMath</creatorcontrib><creatorcontrib>Zoratti, Karla</creatorcontrib><creatorcontrib>Gignoux, Christopher R., MS</creatorcontrib><creatorcontrib>Torgerson, Dara G., PhD</creatorcontrib><creatorcontrib>Galanter, Joshua M., MD</creatorcontrib><creatorcontrib>Huntsman, Scott, MS</creatorcontrib><creatorcontrib>Nguyen, Elizabeth A., BS</creatorcontrib><creatorcontrib>Becker, Allan B., MD</creatorcontrib><creatorcontrib>Chan-Yeung, Moira, MD</creatorcontrib><creatorcontrib>Kozyrskyj, Anita L., PhD</creatorcontrib><creatorcontrib>Kwok, Pui-Yan, MD, PhD</creatorcontrib><creatorcontrib>Gilliland, Frank D., MD, PhD</creatorcontrib><creatorcontrib>Gauderman, W. James, PhD</creatorcontrib><creatorcontrib>Bleecker, Eugene R., MD</creatorcontrib><creatorcontrib>Raby, Benjamin A., MD, MPH</creatorcontrib><creatorcontrib>Meyers, Deborah A., PhD</creatorcontrib><creatorcontrib>London, Stephanie J., MD, DrPH</creatorcontrib><creatorcontrib>Martinez, Fernando D., MD</creatorcontrib><creatorcontrib>Weiss, Scott T., MD, MS</creatorcontrib><creatorcontrib>Burchard, Esteban G., MD, MPH</creatorcontrib><creatorcontrib>Nicolae, Dan L., PhD</creatorcontrib><creatorcontrib>Ober, Carole, PhD</creatorcontrib><creatorcontrib>Barnes, Kathleen C., PhD</creatorcontrib><creatorcontrib>Williams, L. Keoki, MD, MPH</creatorcontrib><title>A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Background IgE is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino subjects have not been well represented in genetic studies of total IgE. Objective We sought to identify the genetic predictors of serum total IgE levels. Methods We used genome-wide association data from 4292 subjects (2469 African Americans, 1564 European Americans, and 259 Latinos) in the EVE Asthma Genetics Consortium. Tests for association were performed within each cohort by race-ethnic group (ie, African American, Latino, and European American) and asthma status. The resulting P values were meta-analyzed, accounting for sample size and direction of effect. Top single nucleotide polymorphism associations from the meta-analysis were reassessed in 6 additional cohorts comprising 5767 subjects. Results We identified 10 unique regions in which the combined association statistic was associated with total serum IgE levels ( P < 5.0 × 10−6 ) and the minor allele frequency was 5% or greater in 2 or more population groups. Variant rs9469220, corresponding to HLA-DQB1 , was the single nucleotide polymorphism most significantly associated with serum total IgE levels when assessed in both the replication cohorts and the discovery and replication sets combined ( P = .007 and 2.45 × 10−7 , respectively). In addition, findings from earlier genome-wide association studies were also validated in the current meta-analysis. Conclusion This meta-analysis independently identified a variant near HLA-DQB1 as a predictor of total serum IgE levels in multiple race-ethnic groups. This study also extends and confirms the findings of earlier genome-wide association analyses in African American and Latino subjects.</description><subject>Adolescent</subject><subject>Adult</subject><subject>African Americans</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Allergies</subject><subject>Allergy and Immunology</subject><subject>Asthma</subject><subject>Asthma - blood</subject><subject>Asthma - ethnology</subject><subject>Asthma - genetics</subject><subject>Asthma - immunology</subject><subject>Biological and medical sciences</subject><subject>Canada - epidemiology</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chronic obstructive pulmonary disease</subject><subject>continental population groups</subject><subject>Ethnicity</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genetics</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Hispanic Americans</subject><subject>HLA-DQ beta-Chains - blood</subject><subject>HLA-DQ beta-Chains - genetics</subject><subject>HLA-DQ beta-Chains - immunology</subject><subject>Humans</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin E - genetics</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>race-ethnicity</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Studies</subject><subject>total IgE</subject><subject>United States - epidemiology</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEokvhD3BAllAlLln8ETu2hCpVVYFKlTgAZ8vrTBYvSbx4kkX773G6Sws9wMny-Jl3ZvxOUbxkdMkoU283y43zYckp4zmwpJQ_KhaMmrpUmsvHxYJSw0pVV-akeIa4ofkutHlanHDBKiU0WxT-gvQwutINrttjQBJbsoYh9lD-DA0Qhxh9cGOIA8FxagIgaWMiCGnqyRhH15Hr9RUJA2nCDhLCLbYn27iduts8fF48aV2H8OJ4nhZf3199ufxY3nz6cH15cVP6mtKxdL7SrBVarUwjKWtrrlumGciKKynA1VoaqleVbL1fSemcEayhrVZc15wrLU6L84Pudlr10HgYxuQ6u02hd2lvowv275chfLPruLNCGlWZOgu8OQqk-GMCHG0f0EPXuQHihJZJRRnVlRb_RwXntZjNyOjrB-gmTin_9ywoZc0qU8lM8QPlU0RM0N71zaid7bYbO9ttZ7vnWLY7J736c-K7lN_-ZuDsCDj0rmuTG3zAe67mMvc4V3934CD7swuQLPoAg4cmJPCjbWL4dx_nD9J9F4aQK36HPeD9vBa5pfbzvJjzXrIsoqih4heFb9zd</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Levin, Albert M., PhD</creator><creator>Mathias, Rasika A., ScD</creator><creator>Huang, Lili, MPH</creator><creator>Roth, Lindsey A., MA</creator><creator>Daley, Denise, PhD</creator><creator>Myers, Rachel A., PhD</creator><creator>Himes, Blanca E., PhD</creator><creator>Romieu, Isabelle, MD, ScD</creator><creator>Yang, Mao, MS</creator><creator>Eng, Celeste, BS</creator><creator>Park, Julie E., MMath</creator><creator>Zoratti, Karla</creator><creator>Gignoux, Christopher R., MS</creator><creator>Torgerson, Dara G., PhD</creator><creator>Galanter, Joshua M., MD</creator><creator>Huntsman, Scott, MS</creator><creator>Nguyen, Elizabeth A., BS</creator><creator>Becker, Allan B., MD</creator><creator>Chan-Yeung, Moira, MD</creator><creator>Kozyrskyj, Anita L., PhD</creator><creator>Kwok, Pui-Yan, MD, PhD</creator><creator>Gilliland, Frank D., MD, PhD</creator><creator>Gauderman, W. 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Keoki, MD, MPH</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130401</creationdate><title>A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations</title><author>Levin, Albert M., PhD ; Mathias, Rasika A., ScD ; Huang, Lili, MPH ; Roth, Lindsey A., MA ; Daley, Denise, PhD ; Myers, Rachel A., PhD ; Himes, Blanca E., PhD ; Romieu, Isabelle, MD, ScD ; Yang, Mao, MS ; Eng, Celeste, BS ; Park, Julie E., MMath ; Zoratti, Karla ; Gignoux, Christopher R., MS ; Torgerson, Dara G., PhD ; Galanter, Joshua M., MD ; Huntsman, Scott, MS ; Nguyen, Elizabeth A., BS ; Becker, Allan B., MD ; Chan-Yeung, Moira, MD ; Kozyrskyj, Anita L., PhD ; Kwok, Pui-Yan, MD, PhD ; Gilliland, Frank D., MD, PhD ; Gauderman, W. James, PhD ; Bleecker, Eugene R., MD ; Raby, Benjamin A., MD, MPH ; Meyers, Deborah A., PhD ; London, Stephanie J., MD, DrPH ; Martinez, Fernando D., MD ; Weiss, Scott T., MD, MS ; Burchard, Esteban G., MD, MPH ; Nicolae, Dan L., PhD ; Ober, Carole, PhD ; Barnes, Kathleen C., PhD ; Williams, L. Keoki, MD, MPH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c700t-ac481f386b9d501f728f181e542653ea785908b45fccb55aa931d0f8628722683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>African Americans</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Allergies</topic><topic>Allergy and Immunology</topic><topic>Asthma</topic><topic>Asthma - blood</topic><topic>Asthma - ethnology</topic><topic>Asthma - genetics</topic><topic>Asthma - immunology</topic><topic>Biological and medical sciences</topic><topic>Canada - epidemiology</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chronic obstructive pulmonary disease</topic><topic>continental population groups</topic><topic>Ethnicity</topic><topic>European Continental Ancestry Group</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genetics</topic><topic>Genome-Wide Association Study</topic><topic>Genomes</topic><topic>Hispanic Americans</topic><topic>HLA-DQ beta-Chains - blood</topic><topic>HLA-DQ beta-Chains - genetics</topic><topic>HLA-DQ beta-Chains - immunology</topic><topic>Humans</topic><topic>Immunoglobulin E - blood</topic><topic>Immunoglobulin E - genetics</topic><topic>Immunoglobulin E - immunology</topic><topic>Immunopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population</topic><topic>race-ethnicity</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Studies</topic><topic>total IgE</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levin, Albert M., PhD</creatorcontrib><creatorcontrib>Mathias, Rasika A., ScD</creatorcontrib><creatorcontrib>Huang, Lili, MPH</creatorcontrib><creatorcontrib>Roth, Lindsey A., MA</creatorcontrib><creatorcontrib>Daley, Denise, PhD</creatorcontrib><creatorcontrib>Myers, Rachel A., PhD</creatorcontrib><creatorcontrib>Himes, Blanca E., PhD</creatorcontrib><creatorcontrib>Romieu, Isabelle, MD, ScD</creatorcontrib><creatorcontrib>Yang, Mao, MS</creatorcontrib><creatorcontrib>Eng, Celeste, BS</creatorcontrib><creatorcontrib>Park, Julie E., MMath</creatorcontrib><creatorcontrib>Zoratti, Karla</creatorcontrib><creatorcontrib>Gignoux, Christopher R., MS</creatorcontrib><creatorcontrib>Torgerson, Dara G., PhD</creatorcontrib><creatorcontrib>Galanter, Joshua M., MD</creatorcontrib><creatorcontrib>Huntsman, Scott, MS</creatorcontrib><creatorcontrib>Nguyen, Elizabeth A., BS</creatorcontrib><creatorcontrib>Becker, Allan B., MD</creatorcontrib><creatorcontrib>Chan-Yeung, Moira, MD</creatorcontrib><creatorcontrib>Kozyrskyj, Anita L., PhD</creatorcontrib><creatorcontrib>Kwok, Pui-Yan, MD, PhD</creatorcontrib><creatorcontrib>Gilliland, Frank D., MD, PhD</creatorcontrib><creatorcontrib>Gauderman, W. James, PhD</creatorcontrib><creatorcontrib>Bleecker, Eugene R., MD</creatorcontrib><creatorcontrib>Raby, Benjamin A., MD, MPH</creatorcontrib><creatorcontrib>Meyers, Deborah A., PhD</creatorcontrib><creatorcontrib>London, Stephanie J., MD, DrPH</creatorcontrib><creatorcontrib>Martinez, Fernando D., MD</creatorcontrib><creatorcontrib>Weiss, Scott T., MD, MS</creatorcontrib><creatorcontrib>Burchard, Esteban G., MD, MPH</creatorcontrib><creatorcontrib>Nicolae, Dan L., PhD</creatorcontrib><creatorcontrib>Ober, Carole, PhD</creatorcontrib><creatorcontrib>Barnes, Kathleen C., PhD</creatorcontrib><creatorcontrib>Williams, L. Keoki, MD, MPH</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levin, Albert M., PhD</au><au>Mathias, Rasika A., ScD</au><au>Huang, Lili, MPH</au><au>Roth, Lindsey A., MA</au><au>Daley, Denise, PhD</au><au>Myers, Rachel A., PhD</au><au>Himes, Blanca E., PhD</au><au>Romieu, Isabelle, MD, ScD</au><au>Yang, Mao, MS</au><au>Eng, Celeste, BS</au><au>Park, Julie E., MMath</au><au>Zoratti, Karla</au><au>Gignoux, Christopher R., MS</au><au>Torgerson, Dara G., PhD</au><au>Galanter, Joshua M., MD</au><au>Huntsman, Scott, MS</au><au>Nguyen, Elizabeth A., BS</au><au>Becker, Allan B., MD</au><au>Chan-Yeung, Moira, MD</au><au>Kozyrskyj, Anita L., PhD</au><au>Kwok, Pui-Yan, MD, PhD</au><au>Gilliland, Frank D., MD, PhD</au><au>Gauderman, W. James, PhD</au><au>Bleecker, Eugene R., MD</au><au>Raby, Benjamin A., MD, MPH</au><au>Meyers, Deborah A., PhD</au><au>London, Stephanie J., MD, DrPH</au><au>Martinez, Fernando D., MD</au><au>Weiss, Scott T., MD, MS</au><au>Burchard, Esteban G., MD, MPH</au><au>Nicolae, Dan L., PhD</au><au>Ober, Carole, PhD</au><au>Barnes, Kathleen C., PhD</au><au>Williams, L. Keoki, MD, MPH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>131</volume><issue>4</issue><spage>1176</spage><epage>1184</epage><pages>1176-1184</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Background IgE is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino subjects have not been well represented in genetic studies of total IgE. Objective We sought to identify the genetic predictors of serum total IgE levels. Methods We used genome-wide association data from 4292 subjects (2469 African Americans, 1564 European Americans, and 259 Latinos) in the EVE Asthma Genetics Consortium. Tests for association were performed within each cohort by race-ethnic group (ie, African American, Latino, and European American) and asthma status. The resulting P values were meta-analyzed, accounting for sample size and direction of effect. Top single nucleotide polymorphism associations from the meta-analysis were reassessed in 6 additional cohorts comprising 5767 subjects. Results We identified 10 unique regions in which the combined association statistic was associated with total serum IgE levels ( P < 5.0 × 10−6 ) and the minor allele frequency was 5% or greater in 2 or more population groups. Variant rs9469220, corresponding to HLA-DQB1 , was the single nucleotide polymorphism most significantly associated with serum total IgE levels when assessed in both the replication cohorts and the discovery and replication sets combined ( P = .007 and 2.45 × 10−7 , respectively). In addition, findings from earlier genome-wide association studies were also validated in the current meta-analysis. Conclusion This meta-analysis independently identified a variant near HLA-DQB1 as a predictor of total serum IgE levels in multiple race-ethnic groups. This study also extends and confirms the findings of earlier genome-wide association analyses in African American and Latino subjects.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>23146381</pmid><doi>10.1016/j.jaci.2012.10.002</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6749 |
| ispartof | Journal of allergy and clinical immunology, 2013-04, Vol.131 (4), p.1176-1184 |
| issn | 0091-6749 1097-6825 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3596497 |
| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult African Americans Aged Aged, 80 and over Allergies Allergy and Immunology Asthma Asthma - blood Asthma - ethnology Asthma - genetics Asthma - immunology Biological and medical sciences Canada - epidemiology Case-Control Studies Child Child, Preschool Chronic obstructive pulmonary disease continental population groups Ethnicity European Continental Ancestry Group Female Fundamental and applied biological sciences. Psychology Fundamental immunology Genetics Genome-Wide Association Study Genomes Hispanic Americans HLA-DQ beta-Chains - blood HLA-DQ beta-Chains - genetics HLA-DQ beta-Chains - immunology Humans Immunoglobulin E - blood Immunoglobulin E - genetics Immunoglobulin E - immunology Immunopathology Male Medical sciences Meta-analysis Middle Aged Polymorphism, Single Nucleotide Population race-ethnicity Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Studies total IgE United States - epidemiology |
| title | A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations |
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