A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations

Background IgE is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino subjects have not been well represented in genetic studies of total IgE. Objective We sought to identify the genetic predictors...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2013-04, Vol.131 (4), p.1176-1184
Hauptverfasser:	Levin, Albert M., PhD, Mathias, Rasika A., ScD, Huang, Lili, MPH, Roth, Lindsey A., MA, Daley, Denise, PhD, Myers, Rachel A., PhD, Himes, Blanca E., PhD, Romieu, Isabelle, MD, ScD, Yang, Mao, MS, Eng, Celeste, BS, Park, Julie E., MMath, Zoratti, Karla, Gignoux, Christopher R., MS, Torgerson, Dara G., PhD, Galanter, Joshua M., MD, Huntsman, Scott, MS, Nguyen, Elizabeth A., BS, Becker, Allan B., MD, Chan-Yeung, Moira, MD, Kozyrskyj, Anita L., PhD, Kwok, Pui-Yan, MD, PhD, Gilliland, Frank D., MD, PhD, Gauderman, W. James, PhD, Bleecker, Eugene R., MD, Raby, Benjamin A., MD, MPH, Meyers, Deborah A., PhD, London, Stephanie J., MD, DrPH, Martinez, Fernando D., MD, Weiss, Scott T., MD, MS, Burchard, Esteban G., MD, MPH, Nicolae, Dan L., PhD, Ober, Carole, PhD, Barnes, Kathleen C., PhD, Williams, L. Keoki, MD, MPH
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult African Americans Aged Aged, 80 and over Allergies Allergy and Immunology Asthma Asthma - blood Asthma - ethnology Asthma - genetics Asthma - immunology Biological and medical sciences Canada - epidemiology Case-Control Studies Child Child, Preschool Chronic obstructive pulmonary disease continental population groups Ethnicity European Continental Ancestry Group Female Fundamental and applied biological sciences. Psychology Fundamental immunology Genetics Genome-Wide Association Study Genomes Hispanic Americans HLA-DQ beta-Chains - blood HLA-DQ beta-Chains - genetics HLA-DQ beta-Chains - immunology Humans Immunoglobulin E - blood Immunoglobulin E - genetics Immunoglobulin E - immunology Immunopathology Male Medical sciences Meta-analysis Middle Aged Polymorphism, Single Nucleotide Population race-ethnicity Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Studies total IgE United States - epidemiology
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Zusammenfassung:	Background IgE is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino subjects have not been well represented in genetic studies of total IgE. Objective We sought to identify the genetic predictors of serum total IgE levels. Methods We used genome-wide association data from 4292 subjects (2469 African Americans, 1564 European Americans, and 259 Latinos) in the EVE Asthma Genetics Consortium. Tests for association were performed within each cohort by race-ethnic group (ie, African American, Latino, and European American) and asthma status. The resulting P values were meta-analyzed, accounting for sample size and direction of effect. Top single nucleotide polymorphism associations from the meta-analysis were reassessed in 6 additional cohorts comprising 5767 subjects. Results We identified 10 unique regions in which the combined association statistic was associated with total serum IgE levels ( P
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2012.10.002