A crowdsourcing evaluation of the NIH chemical probes

Between 2004 and 2008, the US National Institutes of Health Molecular Libraries and Imaging initiative pilot phase funded 10 high-throughput screening centers, resulting in the deposition of 691 assays into PubChem and the nomination of 64 chemical probes. We crowdsourced the Molecular Libraries and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature chemical biology 2009-07, Vol.5 (7), p.441-447
Hauptverfasser:	Oprea, Tudor I, Bologa, Cristian G, Boyer, Scott, Curpan, Ramona F, Glen, Robert C, Hopkins, Andrew L, Lipinski, Christopher A, Marshall, Garland R, Martin, Yvonne C, Ostopovici-Halip, Liliana, Rishton, Gilbert, Ursu, Oleg, Vaz, Roy J, Waller, Chris, Waldmann, Herbert, Sklar, Larry A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemical Engineering Biochemistry Biomedical research Bioorganic Chemistry Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science commentary Crowdsourcing Databases, Factual Decision Making Drug Discovery - economics Drug Discovery - methods Drug Discovery - organization & administration Drug Discovery - standards Molecular biology Molecular Probe Techniques - standards Molecular Probe Techniques - trends Molecular Probes - chemistry National Institutes of Health (U.S.) Probes Small Molecule Libraries - chemistry United States
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Between 2004 and 2008, the US National Institutes of Health Molecular Libraries and Imaging initiative pilot phase funded 10 high-throughput screening centers, resulting in the deposition of 691 assays into PubChem and the nomination of 64 chemical probes. We crowdsourced the Molecular Libraries and Imaging initiative output to 11 experts, who expressed medium or high levels of confidence in 48 of these 64 probes.
ISSN:	1552-4450 1552-4469
DOI:	10.1038/nchembio0709-441