Pathogenesis of Vasculitis in env-pX Rats

Pathogenesis of Vasculitis in env-pX Rats

Transgenic rats carrying the env-pX gene of human T-cell leukemia virus type I (env-pX rats) develop necrotizing angiitis resembling human polyarteritis nodosa (PN). In the development of vasculitis in these rats, the thymus plays an important role. In this review, we provide an outline of the patho...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Annals of Vascular Diseases 2012, Vol.5(3), pp.296-299
Hauptverfasser: Ishizu, Akihiro, Yoshiki, Takashi
Format: Artikel
Sprache:eng
Schlagworte:
animal model
autoreactive T-cell
Review
thymus
vasculitis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Transgenic rats carrying the env-pX gene of human T-cell leukemia virus type I (env-pX rats) develop necrotizing angiitis resembling human polyarteritis nodosa (PN). In the development of vasculitis in these rats, the thymus plays an important role. In this review, we provide an outline of the pathogenesis of vasculitis observed in env-pX rats, and discuss the developmental mechanism of human necrotizing angiitis such as PN with an unknown cause. (*English Translation of J Jpn Coll Angiol 2009; 49: 17-20.)
ISSN:1881-641X
1881-6428
DOI:10.3400/avd.ra.12.00063