Role of the hypothalamic–pituitary–adrenal axis in developmental programming of health and disease

Highlights ► Adverse perinatal environments affect developmental programming of health and disease. ► Reprogramming of the HPA axis is a mechanism that is commonly involved. ► Epigenetic modification of GR gene expression patterns plays a central role in reprogramming of the HPA axis.

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Bibliographische Detailangaben
Veröffentlicht in:	Frontiers in neuroendocrinology 2013-01, Vol.34 (1), p.27-46
Hauptverfasser:	Xiong, Fuxia, Zhang, Lubo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Endocrinology & Metabolism Epigenesis, Genetic - genetics Epigenesis, Genetic - physiology Epigenetic Glucocorticoid receptor Glucocorticoids Humans Hypertension Hypothalamic–pituitary–adrenal axis Hypothalamo-Hypophyseal System - embryology Hypothalamo-Hypophyseal System - growth & development Hypothalamo-Hypophyseal System - metabolism Metabolic disease Neurological dysfunction Pituitary-Adrenal System - embryology Pituitary-Adrenal System - growth & development Pituitary-Adrenal System - metabolism Programming Receptors, Glucocorticoid - genetics Stress, Physiological - physiology
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Beschreibung
Zusammenfassung:	Highlights ► Adverse perinatal environments affect developmental programming of health and disease. ► Reprogramming of the HPA axis is a mechanism that is commonly involved. ► Epigenetic modification of GR gene expression patterns plays a central role in reprogramming of the HPA axis.
ISSN:	0091-3022 1095-6808
DOI:	10.1016/j.yfrne.2012.11.002